Author

A. Dias Costa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Research Focus:clustering· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

J. A. Nowak· 4 shared B. M. Wolpin· 3 shared C. S. Fuchs· 2 shared S. A. Vayrynen· 2 shared A. A. Borah· 1 shared A. Babic· 1 shared A. Bhutkar· 1 shared A. C. Koong· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersCancer Biology

J. A. Nowak

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4 papers

Recent·Most cited

Machine learning links T cell function and spatial localization to neoadjuvant immunotherapy and clinical outcome in pancreatic cancer

K. E. Blise, S. Sivagnanam, C. B. Betts, K. Betre, N. Kirchberger, B. Tate, E. E. Furth, A. Dias Costa, J. A. Nowak, B. M. Wolpin, R. H. Vonderheide, J. Goecks, L. M. Coussens, K. Byrne

This study uses machine learning to analyze spatial proteomic data from pancreatic cancer patients, linking T cell function and localization to neoadjuvant CD40 therapy and clinical outcomes.

bioRxiv · Oct 20, 2023Cancer Biology

The tumor microenvironment drives transcriptional phenotypes and their plasticity in metastatic pancreatic cancer

S. Raghavan, P. S. Winter, A. W. Navia, H. L. Williams, A. DenAdel, R. L. Kalekar, J. Galvez-Reyes, K. E. Lowder, N. Mulugeta, M. S. Raghavan, A. A. Borah, K. S. Kapner, S. A. Vayrynen, A. Dias Costa, R. W. S. Ng, , A. K. Shalek

This study identifies a transitional cancer cell state in metastatic pancreatic cancer and shows that tumor microenvironment signals drive transcriptional plasticity and subtype transitions.

bioRxiv · Aug 25, 2020 · PreprintCancer Biology

Tumor-Immune Partitioning and Clustering (TIPC) algorithm reveals distinct signatures of tumor-immune cell interactions within the tumor microenvironment

M. C. Lau, J. Borowsky, J. P. Vayrynen, K. Haruki, M. Zhao, A. Dias Costa, S. Gu, A. d. Silva, K. Arima, J. Yeong, K. D. Felt, T. Hamada, R. Nishihara, J. K. Lennerz, C. S. Fuchs, , J. A. Nowak

The paper introduces TIPC, a computational algorithm that identifies tumor-immune spatial patterns in colorectal cancer, linking them to patient survival and tumor features.

bioRxiv · May 29, 2020 · PreprintCancer Biology

Endocrine-exocrine signaling drives obesity-associated pancreatic ductal adenocarcinoma

K. M. Chung, J. Singh, L. Lawres, K. J. Dorans, C. Garcia, D. B. Burkhardt, R. Robbins, A. Bhutkar, R. Cardone, X. Zhao, A. Babic, S. A. Vayrynen, A. Dias Costa, J. A. Nowak, D. T. Chang, , M. D. Muzumdar

This study shows obesity accelerates pancreatic cancer by altering the tumor microenvironment, with reversible effects through weight loss.

bioRxiv · Sep 26, 2019Cancer Biology