MCM complexes are barriers that restrict cohesin-mediated loop extrusion
B. J. H. Dequeker, H. B. Brandao, M. J. Scherr, J. Gassler, S. Powell, I. Gaspar, I. M. Flyamer, W. Tang, R. Stocsits, I. F. Davidson, J.-M. Peters, K. E. Duderstadt, L. A. Mirny, K. Tachibana
The paper shows MCM complexes block cohesin-mediated loop extrusion, reducing CTCF-anchored loops and TAD boundary insulation in G1 phase.
bioRxiv · Oct 15, 2020Cell Biology