Author

L. A. Mirny

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 8 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 9 Approach:statistical model· 6 Assay:Hi-C· 4 Assay:ChIP-seq· 3 Organism:human· 3 Organism:bacteria (other)· 2 Approach:experimental assay· 2 Approach:simulation· 2

Frequent Co-Authors

E. J. Banigan· 4 shared H. B. Brandao· 3 shared X. Wang· 2 shared A. A. van den Berg· 1 shared A. Coulon· 1 shared A. van den Berg· 1 shared B. J. H. Dequeker· 1 shared B. Slavov· 1 shared

Activity by Year

2018-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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4 shared papersBiophysics

E. J. Banigan

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Author profile →

9 papers

Recent·Most cited

Design principles of 3D epigenetic memory systems

J. A. Owen, D. Osmanovic, L. A. Mirny

This study shows how 3D genome compartmentalization and enzyme limitation stabilize epigenetic memory through a biophysical model of histone mark spreading.

bioRxiv · Sep 24, 2022Biophysics

Crumpled polymer with loops recapitulates key features of chromosome organization

K. E. Polovnikov, B. Slavov, S. Belan, M. Imakaev, H. Brandao, L. A. Mirny

The paper introduces a physical model of a polymer folded into loops, showing how loops affect contact statistics and reduce topological entanglements in chromosomes.

bioRxiv · Feb 1, 2022Biophysics

Live-cell micromanipulation of a genomic locus reveals interphase chromatin mechanics

V. I. P. Keizer, S. Grosse-Holz, M. Woringer, L. Zambon, K. Aizel, M. Bongaerts, L. Kolar-Znika, V. F. Scolari, S. Hoffmann, E. J. Banigan, L. A. Mirny, M. Dahan, D. Fachinetti, A. Coulon

The paper uses magnetic forces to manipulate a genomic locus in live human cells, revealing chromatin's viscoelastic properties and challenging the gel-like model.

bioRxiv · Apr 20, 2021Biophysics

DNA-loop extruding SMC complexes can traverse one another in vivo

H. B. Brandão, Z. Ren, X. Karaboja, L. A. Mirny, X. Wang

This study investigates how SMC complexes interact when encountering each other on DNA, showing they can traverse, leading to chromosome reorganization and bypassing steric barriers.

bioRxiv · Oct 26, 2020Biophysics

MCM complexes are barriers that restrict cohesin-mediated loop extrusion

B. J. H. Dequeker, H. B. Brandao, M. J. Scherr, J. Gassler, S. Powell, I. Gaspar, I. M. Flyamer, W. Tang, R. Stocsits, I. F. Davidson, J.-M. Peters, K. E. Duderstadt, L. A. Mirny, K. Tachibana

The paper shows MCM complexes block cohesin-mediated loop extrusion, reducing CTCF-anchored loops and TAD boundary insulation in G1 phase.

bioRxiv · Oct 15, 2020Cell Biology

The interplay between asymmetric and symmetric DNA loop extrusion

E. J. Banigan, L. A. Mirny

This study investigates how different DNA loop extrusion mechanisms contribute to chromosome compaction, showing that two-sided extrusion and stable binding enhance compaction.

bioRxiv · Sep 22, 2020Biophysics

Chromosome organization by one-sided and two-sided loop extrusion

E. J. Banigan, A. A. van den Berg, H. B. Brandao, J. F. Marko, L. A. Mirny

This study investigates one-sided and two-sided loop extrusion by SMC complexes, showing that one-sided extrusion cannot recapitulate in vivo observations but variants can, suggesting SMC complexes may function as two-sided motors or have biased loading.

bioRxiv · Apr 2, 2020Biophysics

RNA polymerases as moving barriers to condensin loop extrusion

H. B. Brandao, X. Wang, P. Paul, A. van den Berg, D. Z. Rudner, L. A. Mirny

This study quantitatively investigates how RNA polymerases interact with condensin loop extrusion, showing RNAPs act as steric barriers that impede the process, particularly in highly transcribed regions.

bioRxiv · Apr 10, 2019Biophysics

Limits of chromosome compaction by loop-extruding motors

E. J. Banigan, L. A. Mirny

The paper models chromosome compaction by loop-extruding motors and finds one-sided extrusion can only achieve ~10-fold compaction, suggesting other mechanisms are needed for full compaction.

bioRxiv · Nov 21, 2018Biophysics