Author

R. Ghouil

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

S. ZINN-JUSTIN· 4 shared S. Miron· 3 shared A.-A. Arteni· 2 shared D. Loew· 2 shared F. Dingli· 2 shared F.-X. Theillet· 2 shared M. Ouldali· 2 shared A. Alik· 1 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersCell Biology

S. ZINN-JUSTIN

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

KIF2C-induced nuclear condensation concentrates PLK1 and phosphorylated BRCA2 at the kinetochore microtubules in mitosis

A. Skobelkina, M. Julien, S. Jeannin, S. Miron, T. Egger, R. Chaaban, G. Bouvignies, R. Ghouil, C. Friel, D. BUSSO, F.-X. Theillet, R. Le Bars, A. Carreira, A. Constantinou, J. Basbous, S. ZINN-JUSTIN

The paper shows KIF2C forms condensates during mitosis that concentrate PLK1 and phosphorylated BRCA2 at kinetochore microtubules, enhancing their kinase activity and attachment stability.

bioRxiv · Apr 13, 2024Cell Biology

BRCA2-HSF2BP Oligomeric Ring Disassembly by BRME1 Promotes Homologous Recombination

R. Ghouil, S. Miron, K. Sato, D. Ristic, S. E. van Rossum-Fikkert, P. Legrand, M. Ouldali, J.-M. Winter, V. Ropars, G. David, A.-A. Arteni, C. Wyman, P. Knipscheer, R. Kanaar, A. N. Zelensky, S. Zinn-Justin

The paper shows that BRME1 disrupts the HSF2BP-BRCA2 ring complex, preventing BRCA2 degradation and promoting homologous recombination in meiosis.

bioRxiv · Apr 27, 2023Biochemistry

Polθ is phosphorylated by Polo-like kinase 1 (PLK1) to enable repair of DNA double strand breaks in mitosis

C. Gelot, M. T. Kovacs, S. Miron, E. Mylne, R. Ghouil, T. Popova, F. Dingli, D. Loew, J. Guirouilh-Barbat, E. Del Nery, S. Zinn-Justin, R. Ceccaldi

This study identifies Polθ as a key factor in repairing DNA double strand breaks during mitosis, showing that its phosphorylation by PLK1 enables this process and maintains genome integrity.

bioRxiv · Mar 17, 2023Cell Biology

Structural characterization of stem cell factors Oct4, Sox2, Nanog and Esrrb disordered domains, and a method to identify their phospho-dependent binding partners.

F.-X. Theillet, C. Bouguechtouli, R. Ghouil, A. Alik, F. Dingli, D. Loew

The paper structurally characterizes disordered domains of pluripotency transcription factors and presents a method to identify their phospho-dependent binding partners using NMR and proteomics.

bioRxiv · Mar 5, 2023Biochemistry

Structural analysis of Toxoplasma gondii sortilin

A. Honfozo, R. Ghouil, T. D. Alayi, M. Ouldali, A.-A. Arteni, C. M. Atindehou, L. A. Fanou, Y. Hathout, S. Zinn-Justin, S. Tomavo

This study identifies TgSORT as an essential cargo receptor in Toxoplasma gondii and presents its structural analysis using molecular modeling and electron microscopy.

bioRxiv · Nov 17, 2022 · PreprintCell Biology