E. Del Nery

COMBINATION THERAPIES TARGETING ALK-ABERRANT NEUROBLASTOMA IN PRECLINICAL MODELS.

This study evaluates lorlatinib, an ALK inhibitor, in combination with chemotherapy or idasanutlin in preclinical neuroblastoma models, finding synergy in models with high ALK expression.

Polθ is phosphorylated by Polo-like kinase 1 (PLK1) to enable repair of DNA double strand breaks in mitosis

This study identifies Polθ as a key factor in repairing DNA double strand breaks during mitosis, showing that its phosphorylation by PLK1 enables this process and maintains genome integrity.

Prostaglandin E1 as therapeutic molecule for Nephronophthisis and related ciliopathies

This study identifies PGE1 as a potential therapeutic for NPH-associated ciliopathies, showing it rescues ciliogenesis and improves kidney phenotypes in models.

Homosalate boosts the release of tumor-derived Extracellular Vesicles with anti-anoikis properties

The paper identifies Homosalate as a drug that increases EV release from triple negative breast cancer cells, which have anti-anoikis properties.

Discovery of genes that modulate flavivirus replication in an interferon-dependent manner

The paper identifies twenty-one host genes that modulate flavivirus replication in an interferon-dependent manner using siRNA screening in ZIKV-infected microglial cells.

Small molecule enhancers of endosome-to-cytosol import augment anti-tumour immunity

The paper identifies small molecule enhancers of endosome-to-cytosol antigen import that improve cross-presentation and anti-tumour immunity.

Regulation of eIF4F complex by the peptidyl prolyl isomerase FKBP7 in taxane-resistant prostate cancer

This study identifies FKBP7 as a molecular chaperone that regulates the eIF4F complex in taxane-resistant prostate cancer, and shows that inhibiting eIF4A can overcome resistance.