Author

L. S. Itzhaki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:plant (other)· 1 Assay:proteomics· 1

Frequent Co-Authors

D. Bauer· 2 shared M. Rief· 2 shared M. Synakewicz· 2 shared A. A. Vinogradov· 1 shared A. Perez-Riba· 1 shared A. Weissl· 1 shared B. M. Smith· 1 shared C. M. Dobson· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiophysics

D. Bauer

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4 papers

Recent·Most cited

Targeting the Plasmodium falciparum UCHL3 ubiquitin hydrolase using chemically constrained peptides

H. R. King, M. Bycroft, T.-B. Nguyen, G. Kelly, A. A. Vinogradov, P. J. Rowling, K. Stott, D. B. Ascher, H. Suga, L. S. Itzhaki, K. Artavanis-Tsakonas

This study identifies chemically constrained peptides that inhibit PfUCHL3, a critical deubiquitinating enzyme in Plasmodium falciparum, by blocking substrate binding rather than active site interaction.

bioRxiv · Jan 11, 2024 · PreprintBiophysics

Parallel and sequential pathways of molecular recognition of a tandem-repeat protein and its intrinsically disordered binding partner

B. M. Smith, P. J. E. Rowling, C. M. Dobson, L. S. Itzhaki

This study investigates the kinetic mechanisms of TCF7L2 binding to β-catenin, revealing a two-site avidity model with parallel dissociation pathways.

bioRxiv · Apr 15, 2021Biophysics

Consensus tandem tetratricopeptide repeat proteins are complex superhelical nanosprings

M. Synakewicz, R. Eapen, A. Perez-Riba, D. Bauer, A. Weissl, G. Fischer, M. Hyvonen, M. Rief, L. S. Itzhaki, J. Stigler

This study investigates the mechanical properties of consensus-designed tetratricopeptide repeats (CTPRs) using single-molecule techniques, revealing their spring-like behavior and superhelical structure.

bioRxiv · Mar 27, 2021Biophysics

Bioorthogonal protein-DNA conjugation methods for force spectroscopy

M. Synakewicz, D. Bauer, M. Rief, L. S. Itzhaki

This paper introduces bioorthogonal methods for site-specific DNA-protein conjugation to improve force spectroscopy techniques, expanding the range of proteins that can be studied.

bioRxiv · May 21, 2019Biophysics