Antibiotic transport kinetics in Gram-negative bacteria revealed via single-cell uptake analysis and mathematical modelling
J. Cama, M. Voliotis, J. Metz, A. Smith, J. Iannucci, U. F. Keyser, K. Tsaneva-Atanasova, S. Pagliara
This study quantifies antibiotic uptake in E. coli using microfluidics and microscopy, showing growth phase impacts drug accumulation more than transport pathways, and develops a mathematical model to predict kinetics.
bioRxiv · Dec 6, 2019Biophysics