J. J. Chou

Structural basis of γ-chain family receptor sharing at the membrane level

The study identifies direct transmembrane domain interactions as critical for gamma-chain family receptor sharing and activation.

A trimeric hydrophobic zipper mediates the intramembrane assembly of SARS-CoV-2 spike

The paper determines the NMR structure of the SARS-CoV-2 spike protein transmembrane domain, revealing a trimeric hydrophobic zipper that stabilizes the trimer and can be disrupted by specific mutations.

Amphipathic Bax core dimer forms part of apoptotic pore wall in the mitochondrial membrane

This study determines the structure of the Bax core dimer and shows it forms part of the mitochondrial pore wall during apoptosis.

Structural characterization of the N-terminal domain of the Dictyostelium discoideum mitochondrial calcium uniporter

This study reports the crystal structure of the N-terminal domain of DdMCU and shows its oligomeric state and calcium-dependent dissociation.

DNA-mediated assembly of multi-specific antibodies for T cell engaging and tumor killing

This paper describes a method to assemble multi-specific antibodies using DNA-mediated assembly, showing efficacy in tumor cell cytotoxicity and xenograft suppression.