Author

D. W. Andrews

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:protein structure· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

J. Lin· 2 shared A. Ahlner· 1 shared A. F. Lingappa· 1 shared A. Kitaygorodskyy· 1 shared A. Lemak· 1 shared A. Mueller-Schiffmann· 1 shared A. Nalca· 1 shared A. Piai· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

J. Lin

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Author profile →

3 papers

Recent·Most cited

Small Molecule Protein Assembly Modulators with Pan-Cancer Therapeutic Efficacy

A. F. Lingappa, O. Akintunde, C. Ewald, M. Froehlich, N. Ziari, M. Michon, S. F. Yu, S. Mallesh, J. Lin, A. Kitaygorodskyy, D. Solas, J. C. Reed, J. R. Lingappa, A. Mueller-Schiffmann, C. Korth, , V. R. Lingappa

The paper identifies two small molecules with pan-cancer cytotoxicity and validates their anti-tumor effects in xenograft models, showing they target TRIM28/KAP1-containing complexes involved in cancer survival.

bioRxiv · Sep 28, 2022Cancer Biology

The PNUTS-PAD domain recruits MYC to the PNUTS:PP1 phosphatase complex via the oncogenic MYC-MB0 region

Y. Wei, A. Ahlner, C. Redel, A. Lemak, I. Johansson-Akhe, S. Houliston, T. M. G. Kenney, A. Tamachi, V. Morad, S. Duan, D. W. Andrews, B. Wallner, M. Sunnerhagen, C. H. Arrowsmith, L. Z. Penn

This paper identifies the MB0 region of MYC as a direct binder to the PNUTS amino-terminal domain (PAD), revealing a molecular mechanism for MYC regulation by the PNUTS:PP1 phosphatase complex.

bioRxiv · Dec 2, 2021Cancer Biology

Amphipathic Bax core dimer forms part of apoptotic pore wall in the mitochondrial membrane

F. Lv, F. Qi, Z. Zhang, M. Wen, A. Piai, L. Du, L. Zhou, Y. Yang, B. Wu, Z. Liu, J. d. Rosario, J. J. Chou, D. W. Andrews, J. Lin, B. OuYang

This study determines the structure of the Bax core dimer and shows it forms part of the mitochondrial pore wall during apoptosis.

bioRxiv · Dec 18, 2020Biophysics