Author

P. J. Eswara

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 10

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Organism:bacteria (other)· 6 Research Focus:cell type annotation· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:development & morphogenesis· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1

Frequent Co-Authors

M. D. Sacco· 4 shared Y. Chen· 4 shared L. N. Shaw· 3 shared L. R. Hammond· 3 shared S. J. Khan· 3 shared B. Tomlinson· 2 shared L. Hammond· 2 shared R. Brzozowski· 2 shared

Activity by Year

2018-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersMicrobiology

M. D. Sacco

Mutual co-authors in cluster

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10 papers

Recent·Most cited

Staphylococcus aureus FtsZ and PBP4 bind to the conformationally dynamic N-terminal domain of GpsB

M. D. Sacco, L. R. Hammond, R. E. Noor, D. Bhattacharya, J. J. Madsen, X. Zhang, S. G. Butler, M. T. Kemp, A. C. Jaskolka-Brown, S. J. Khan, I. Gelis, P. J. Eswara, Y. Chen

This study determines the structure of S. aureus GpsB's N-terminal domain, revealing its interaction with FtsZ and PBP4, and shows its essential role in cell division.

bioRxiv · Oct 25, 2022Microbiology

Assessing the role of cold-shock protein C: A novel regulator of Acinetobacter baumannii biofilm formation and virulence

B. Tomlinson, G. A. Denham, R. Brzozowski, J. L. Allen, P. J. Eswara, L. N. Shaw

This study identifies cold-shock protein C as a key regulator of biofilm formation and virulence in Acinetobacter baumannii through transcriptomic and functional analyses.

Infection and Immunity · Oct 20, 2022Peer-reviewedMicrobiology

Bacterial threat assessment of bacteriophage infection is mediated by intracellular polyamine accumulation and Gac/Rsm signaling

C. D. de Mattos, A. Nemudryi, D. Faith, D. C. Bublitz, L. Hammond, M. Kinnersley, C. M. Schwartzkopf, A. J. Robinson, A. Joyce, L. A. Michaels, R. Brzozowski, A. Coluccio, D. Xing, J. Uchiyama, L. K. Jennings, , P. R. Secor

This study shows that Pseudomonas aeruginosa uses intracellular polyamine accumulation and Gac/Rsm signaling to assess bacterial cell death and inhibit phage replication.

bioRxiv · Apr 1, 2022Microbiology

MraZ is a transcriptional inhibitor of cell division in Bacillus subtilis

M. L. White, A. Hough-Neidig, S. J. Khan, P. J. Eswara

This study shows that MraZ represses its own operon, leading to filamentation and Z-ring de-condensation in Bacillus subtilis by inhibiting FtsL, which is critical for Z-ring maturation.

bioRxiv · Feb 9, 2022 · PreprintMicrobiology

A unique class of Zn2+-binding PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile

M. D. Sacco, S. Wang, S. R. Adapa, X. Zhang, M. V. Gongora, J. R. Gatdula, E. M. Lewandowski, L. R. Hammond, J. A. Townsend, M. T. Marty, J. Wang, P. J. Eswara, R. H. Y. Jiang, X. Sun, Y. Chen

This study identifies PBP2 as the primary target of cephalosporins in C. difficile and reveals a unique Zn2+-binding motif in PBP2 and related PBPs that contributes to cephalosporin resistance and sporulation.

bioRxiv · Jan 4, 2022 · PreprintMicrobiology

GpsB coordinates cell division and cell surface decoration by wall teichoic acids in Staphylococcus aureus

L. R. Hammond, S. J. Khan, M. D. Sacco, C. Spanoudis, A. Hough, Y. Chen, P. J. Eswara

This study identifies GpsB's role in coordinating cell division and wall teichoic acid biosynthesis in Staphylococcus aureus through interactions with PBPs and the WTA export complex.

bioRxiv · Sep 29, 2021Microbiology

Phenogenomic characterization of a newly domesticated and novel species from the genus Verrucosispora

S. Kennedy, C. Atkinson, B. Tomlinson, L. Hammond, P. J. Eswara, B. J. Baker, L. N. Shaw

This study domesticates a novel marine Actinomycetes species, revealing genomic changes linked to growth, metabolism, and antibiotic potential during cultivation.

bioRxiv · Jul 1, 2021Microbiology

Effect of sunlight on the efficacy of commercial antibiotics used in agriculture

S. Khan, A. Osborn, P. J. Eswara

This study evaluates how sunlight affects the efficacy of streptomycin and oxytetracycline against Gram-negative and Gram-positive bacteria over 7-14 days.

bioRxiv · Jul 10, 2020Microbiology

Suppressors of YpsA-mediated cell division inhibition in Bacillus subtilis

R. S. Brzozowski, B. R. Tomlinson, M. D. Sacco, J. J. Chen, A. N. Ali, Y. Chen, L. N. Shaw, P. J. Eswara

This study identifies suppressor mutations in Bacillus subtilis that alleviate YpsA-mediated cell division inhibition, revealing YfhS's role in cell size regulation.

bioRxiv · Feb 12, 2020 · PreprintMicrobiology

Discovery of the role of a SLOG superfamily biological conflict systems associated protein IodA (YpsA) in oxidative stress protection and cell division inhibition in Gram-positive bacteria

R. S. Brzozowski, G. Graham, A. M. Burroughs, M. Huber, M. Walker, S. S. Alva, L. Aravind, P. J. Eswara

This paper identifies YpsA, a SLOG superfamily protein in Bacillus subtilis, as a regulator of cell division and oxidative stress response, with conserved function in Staphylococcus aureus.

bioRxiv · Oct 24, 2018Microbiology