Author

M. D. Sacco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Pharmacology & Toxicology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:drug response / drug discovery· 3 Organism:virus· 3 Research Focus:cell type annotation· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Organism:C. elegans· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Y. Chen· 8 shared J. Wang· 5 shared X. ZhangiD· 5 shared P. J. Eswara· 4 shared Y. Hu· 4 shared C. Ma· 3 shared J. A. Townsend· 3 shared L. R. Hammond· 3 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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8 shared papersMicrobiology

Y. Chen

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Staphylococcus aureus FtsZ and PBP4 bind to the conformationally dynamic N-terminal domain of GpsB

M. D. Sacco, L. R. Hammond, R. E. Noor, D. Bhattacharya, J. J. Madsen, X. Zhang, S. G. Butler, M. T. Kemp, A. C. Jaskolka-Brown, S. J. Khan, I. Gelis, P. J. Eswara, Y. Chen

This study determines the structure of S. aureus GpsB's N-terminal domain, revealing its interaction with FtsZ and PBP4, and shows its essential role in cell division.

bioRxiv · Oct 25, 2022Microbiology

The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition

M. D. Sacco, Y. Hu, M. V. Gongora, F. Meilleur, M. T. Kemp, X. Zhang, J. Wang, Y. Chen

This study examines the P132H mutation in Omicron SARS-CoV-2 Mpro, finding it reduces thermal stability without affecting catalytic activity or drug inhibition.

bioRxiv · Jan 26, 2022Microbiology

A unique class of Zn2+-binding PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile

M. D. Sacco, S. Wang, S. R. Adapa, X. Zhang, M. V. Gongora, J. R. Gatdula, E. M. Lewandowski, L. R. Hammond, J. A. Townsend, M. T. Marty, J. Wang, P. J. Eswara, R. H. Y. Jiang, X. Sun, Y. Chen

This study identifies PBP2 as the primary target of cephalosporins in C. difficile and reveals a unique Zn2+-binding motif in PBP2 and related PBPs that contributes to cephalosporin resistance and sporulation.

bioRxiv · Jan 4, 2022 · PreprintMicrobiology

GpsB coordinates cell division and cell surface decoration by wall teichoic acids in Staphylococcus aureus

L. R. Hammond, S. J. Khan, M. D. Sacco, C. Spanoudis, A. Hough, Y. Chen, P. J. Eswara

This study identifies GpsB's role in coordinating cell division and wall teichoic acid biosynthesis in Staphylococcus aureus through interactions with PBPs and the WTA export complex.

bioRxiv · Sep 29, 2021Microbiology

An expedited approach towards the rationale design of non-covalent SARS-CoV-2 main protease inhibitors with in vitro antiviral activity

N. Kitamura, M. D. Sacco, C. Ma, Y. Hu, J. Townsend, X. Meng, F. Zhang, X. Zhang, A. Kukuljac, M. Marty, D. Schultz, S. Cherry, Y. Xiang, Y. Chen, J. Wang

This study designs non-covalent SARS-CoV-2 Mpro inhibitors using structure-based design and Ugi-4CR reactions, identifying 23R as the most potent compound with antiviral activity.

bioRxiv · Dec 19, 2020 · PreprintPharmacology & Toxicology

Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against Mpro and cathepsin L

M. D. Sacco, C. Ma, P. Lagarias, A. Gao, J. A. Townsend, X. Meng, P. Dube, X. Zhang, Y. Hu, N. Kitamura, B. Hurst, B. Tarbet, M. T. Marty, A. Kolocouris, Y. Xiang, , J. Wang

This study determines the structure of SARS-CoV-2 Mpro with calpain inhibitors and analogues, revealing new insights for developing dual inhibitors against Mpro and cathepsin L.

Science Advances · Dec 11, 2020Peer-reviewedBiophysics

Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease

C. Ma, M. D. Sacco, B. Hurst, J. A. Townsend, Y. Hu, T. Szeto, X. Zhang, B. Tarbet, M. T. Marty, Y. Chen, J. Wang

This study identifies inhibitors of SARS-CoV-2 main protease that show potent antiviral activity in cell culture.

Cell Research · Jun 15, 2020Peer-reviewedPharmacology & Toxicology

Suppressors of YpsA-mediated cell division inhibition in Bacillus subtilis

R. S. Brzozowski, B. R. Tomlinson, M. D. Sacco, J. J. Chen, A. N. Ali, Y. Chen, L. N. Shaw, P. J. Eswara

This study identifies suppressor mutations in Bacillus subtilis that alleviate YpsA-mediated cell division inhibition, revealing YfhS's role in cell size regulation.

bioRxiv · Feb 12, 2020 · PreprintMicrobiology