J. J. O'Connor

This paper shows PARP12 inhibits replication of a Mac1 mutant coronavirus in some cell and tissue types but not all, suggesting other PARPs also contribute to antiviral defense.

This study shows that SARS-CoV-2 Mac1 is essential for pathogenesis but not replication, as Mac1-deleted virus replicates normally but induces higher IFN responses and reduced disease in mice.

This study shows that a MHV macrodomain mutant with reduced ADP-ribose binding is more attenuated than a mutant with reduced hydrolysis, indicating distinct roles for Mac1 functions in coronavirus replication.