C. A. Miller

Endotoxin, unidentified material, and low amounts of defined toxicants are confounding factors when using the air pollution Standard Reference Material (SRM) 2786 in biological experiments

This paper warns that SRM 2786 contains endotoxin and uncharacterized materials that may confound biological experiments.

SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice

This study shows that SARS-CoV-2 Mac1 is essential for pathogenesis but not replication, as Mac1-deleted virus replicates normally but induces higher IFN responses and reduced disease in mice.

Genomic and transcriptomic somatic alterations of hepatocellular carcinoma in non-cirrhotic livers

This study identifies genomic and transcriptomic alterations in non-cirrhotic hepatocellular carcinoma, revealing recurrent mutations and structural variants that may contribute to tumorigenesis.

U2AF1 is a haplo-essential gene required for cancer cell survival

This study shows that U2AF1 is a haplo-essential gene for cancer cell survival, as mutant cells depend on residual wild-type U2AF1 for viability and are sensitive to its reduction.

Clinicopathologic features of a feline SARS-CoV-2 infection model parallel acute COVID-19 in humans

This study demonstrates that intra-tracheal inoculation of SARS-CoV-2 in cats produces clinical and pathological features similar to severe human COVID-19.

Discovery of a Novel, Selective and Short-Acting Skeletal Myosin II Inhibitor

This study discovers and characterizes skeletostatins, selective skeletal myosin II inhibitors with improved properties for research and drug development.

A Simple and Robust Cell Based Assay for the Discovery of Novel Cytokinesis Inhibitors

This paper develops a cell-based assay to identify cytokinesis inhibitors, showing reliable EC50 values and good separation between positive and negative controls.

Temporal and Clonal Progression in a Pediatric Ependymoma Patient Through Multiple Treatments

This study tracks the molecular evolution of a pediatric ependymoma through multiple treatments, revealing how therapy shapes tumor subclonal diversity and neo-antigen landscapes.