Author

C. M. Kerr

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

J. J. O'Connor· 4 shared A. R. Fehr· 3 shared S. More· 3 shared S. Parthasarathy· 3 shared D. K. Johnson· 2 shared J. J. Pfannenstiel· 2 shared N. Schwarting· 2 shared R. Channappanavar· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersMicrobiology

J. J. O'Connor

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4 papers

Recent·Most cited

Mutation of a highly conserved isoleucine residue in loop 2 of several ????-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental to infection

C. M. Kerr, J. J. Pfannenstiel, Y. M. Alhammad, J. J. O'Connor, R. Ghimire, R. Shrestha, R. Khattabi, P. Saenjamsai, S. Parthasarathy, P. R. McDonald, P. Gao, D. K. Johnson, S. More, A. Roy, R. Channappanavar, A. R. Fehr

This study shows that mutating a conserved isoleucine in the macrodomain of MERS-CoV and SARS-CoV-2 enhances ADP-ribose binding but reduces viral replication and pathogenesis.

bioRxiv · Jan 3, 2024 · PreprintMicrobiology

PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell and tissue specific manner

C. M. Kerr, S. Parthasarathy, N. Schwarting, J. J. O'Connor, E. Giri, S. More, R. C. Orozco, A. R. Fehr

This paper shows PARP12 inhibits replication of a Mac1 mutant coronavirus in some cell and tissue types but not all, suggesting other PARPs also contribute to antiviral defense.

bioRxiv · Jun 16, 2023 · PreprintMicrobiology

SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice

Y. M. Alhammad, S. Parthasarathy, R. Ghimire, J. J. O'Connor, C. M. Kerr, J. J. Pfannenstiel, D. Chanda, C. A. Miller, R. Unckless, S. Zuniga, L. Enjuanes, S. More, R. Channappanavar, A. Fehr

This study shows that SARS-CoV-2 Mac1 is essential for pathogenesis but not replication, as Mac1-deleted virus replicates normally but induces higher IFN responses and reduced disease in mice.

bioRxiv · Apr 6, 2023 · PreprintMicrobiology

An MHV macrodomain mutant predicted to lack ADP-ribose binding activity is severely attenuated, indicating multiple roles for the macrodomain in coronavirus replication

L. S. Voth, J. J. O'Connor, C. M. Kerr, E. Doerger, N. Schwarting, P. Sperstad, D. K. Johnson, A. R. Fehr

This study shows that a MHV macrodomain mutant with reduced ADP-ribose binding is more attenuated than a mutant with reduced hydrolysis, indicating distinct roles for Mac1 functions in coronavirus replication.

bioRxiv · Mar 30, 2021 · PreprintMicrobiology