Author

L. S. Voth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:variant calling· 1

Frequent Co-Authors

A. R. Fehr· 2 shared C. Brenner· 1 shared C. D. Heer· 1 shared C. M. Kerr· 1 shared D. J. Sanderson· 1 shared D. K. Johnson· 1 shared E. Doerger· 1 shared J. J. O'Connor· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

A. R. Fehr

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2 papers

Recent·Most cited

An MHV macrodomain mutant predicted to lack ADP-ribose binding activity is severely attenuated, indicating multiple roles for the macrodomain in coronavirus replication

L. S. Voth, J. J. O'Connor, C. M. Kerr, E. Doerger, N. Schwarting, P. Sperstad, D. K. Johnson, A. R. Fehr

This study shows that a MHV macrodomain mutant with reduced ADP-ribose binding is more attenuated than a mutant with reduced hydrolysis, indicating distinct roles for Mac1 functions in coronavirus replication.

bioRxiv · Mar 30, 2021 · PreprintMicrobiology

Coronavirus infection and PARP expression dysregulate the NAD Metabolome: an actionable component of innate immunity

C. D. Heer, D. J. Sanderson, L. S. Voth, Y. M. O. Alhammad, M. S. Schmidt, S. A. J. Trammell, S. Perlman, M. S. Cohen, A. R. Fehr, C. Brenner

This study shows that SARS-CoV-2 infection upregulates MARylating PARPs and NAD synthesis enzymes, and that enhancing NAD levels can reduce viral replication.

bioRxiv · Apr 17, 2020Microbiology