D. L. Mould

Loss of LasR function leads to decreased repression of Pseudomonas aeruginosa PhoB activity at physiological phosphate concentrations

This paper shows that loss of LasR function in Pseudomonas aeruginosa increases PhoB activity at physiological phosphate concentrations, contributing to increased virulence.

Citrate cross-feeding between Pseudomonas aerguinosa genotypes supports lasR mutant fitness

The paper identifies citrate cross-feeding between Pseudomonas aeruginosa genotypes as a mechanism that enhances fitness and virulence in lasR mutant strains.

Citrate cross-feeding between Pseudomonas aerguinosa genotypes supports lasR mutant fitness in co-cultures

The paper shows that citrate cross-feeding between Pseudomonas aeruginosa genotypes enhances fitness of lasR mutants in co-cultures by enabling citrate uptake and virulence factor expression.

Metabolic basis for the evolution of a common pathogenic Pseudomonas aeruginosa variant

The paper shows that metabolic regulation differences explain the frequent occurrence of lasR loss-of-function mutations in Pseudomonas aeruginosa, linking them to disease severity and evolution.

Host lung environment limits Aspergillus fumigatus germination through a SskA-dependent signaling response

The paper identifies a SskA-dependent signaling pathway that limits Aspergillus fumigatus germination in the host lung environment, enhancing disease initiation and inflammation.

Pseudomonas aeruginosa and Candida albicans both accumulate greater biomass in dual species biofilms under flow

This study shows that Pseudomonas aeruginosa and Candida albicans accumulate more biomass in dual-species biofilms under flow compared to single-species biofilms.

Intra-species signaling between distinct Pseudomonas aeruginosa genotypes increases production of quorum sensing controlled virulence factors

The paper shows that interactions between Pseudomonas aeruginosa genotypes with different LasR function increase virulence factor production through reciprocal signaling.

Ethanol stimulates trehalose production through a SpoT-DksA-AlgU dependent pathway in Pseudomonas aeruginosa

This paper shows ethanol induces trehalose production in Pseudomonas aeruginosa via a SpoT-DksA-AlgU pathway and AHL quorum sensing, dependent on growth phase.