Author

T. M. Hohl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 6 Approach:experimental assay· 5 Organism:mouse· 5 Assay:metagenomics· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

K. A. M. Mills· 3 shared J. B. Xavier· 2 shared J. U. Peled· 2 shared K.-W. Liu· 2 shared M. Aufiero· 2 shared M. R. M. van den Brink· 2 shared R. A. Cramer· 2 shared A. Ballabio· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersImmunology

K. A. M. Mills

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

GM-CSF-mediated epithelial-immune cell crosstalk orchestrates pulmonary immunity to Aspergillus fumigatus

K. A. M. Mills, F. Westermann, V. Espinosa, E. Rosiek, J. V. Desai, M. A. Aufiero, Y. Guo, K. A. Mitchell, S. Tuzlak, D. De Feo, M. S. Lionakis, A. Rivera, B. Becher, T. M. Hohl

This study identifies GM-CSF produced by SPC+ epithelial cells as critical for neutrophil-mediated immunity against Aspergillus fumigatus, enhancing fungal killing and host survival.

bioRxiv · Jan 3, 2024 · PreprintImmunology

Dectin-1/CARD9-induction of the TFEB and TFE3 gene network is dispensable for phagocyte anti-Aspergillus activity in the lung

M. Aufiero, N. Shlezinger, M. Gjonbalaj, K. A. M. Mills, A. Ballabio, T. M. Hohl

This study shows that TFEB and TFE3 activation by Dectin-1/CARD9 in myeloid phagocytes is not essential for anti-Aspergillus activity in the lung despite promoting macrophage fungicidal activity in vitro.

bioRxiv · Jun 13, 2023 · PreprintImmunology

Aspergillus fumigatus cytochrome c impacts conidial survival during sterilizing immunity

M. R. James, M. Aufiero, E. M. Vesely, S. Dhingra, K.-W. Liu, T. M. Hohl, R. A. Cramer

This study shows that loss of cytochrome c in Aspergillus fumigatus reduces susceptibility to ROS-induced cell death and host leukocyte killing.

bioRxiv · Jun 7, 2023 · PreprintMicrobiology

Inflammatory ER Stress Responses Dictate the Immunopathogenic Progression of Systemic Candidiasis

D. Awasthi, S. Chopra, B. A. Cho, A. Emmanuelli, T. A. Sandoval, S.-M. Hwang, C.-S. Chae, C. Salvagno, C. Tan, L. Vasquez-Urbina, J. J. Fernandez Rodriguez, S. F. Santagostino, T. R. Iwawaki, E. A. Romero-Sandoval, M. Sanchez Crespo, , J. R. Cubillos-Ruiz

This study shows that IRE1 hyperactivation in myeloid cells during Candida albicans infection drives renal immunopathology and mortality, and inhibiting IRE1 reduces inflammation and improves survival.

bioRxiv · Nov 17, 2022Immunology

A High Fraction of Oral Bacteria in the Feces Indicates Gut Microbiota Depletion with Implications for Human Health

C. Liao, T. Rolling, A. Djukovic, T. Fei, V. Mishra, H. Liu, C. Lindberg, L. Dai, B. Zhai, J. U. Peled, M. R. M. van den Brink, T. M. Hohl, J. B. Xavier

The paper investigates the association between oral bacteria in feces and gut microbiota depletion, supporting the Marker hypothesis over the Expansion hypothesis.

bioRxiv · Oct 24, 2022Microbiology

Strain specific persistence in the murine lung of Aspergillus fumigatus conidia causes an Allergic Broncho-Pulmonary Aspergillosis-like disease phenotype

J. T. Jones, K.-W. Liu, X. Wang, C. H. Kowalski, B. S. Ross, K. A. M. Mills, J. D. Kerkaert, T. M. Hohl, L. A. Lofgren, J. E. Stajich, J. J. Obar, R. A. Cramer

This study identifies an A. fumigatus strain, W72310, that persists in the mouse lung and causes ABPA-like disease without significant hyphal growth.

bioRxiv · Dec 4, 2020Microbiology

An association between the gut microbiota and immune cell dynamics in humans.

J. Schluter, J. U. Peled, B. P. Taylor, M. Smith, K. A. Markey, Y. Taur, R. Niehus, A. Staffas, A. Dai, E. Fontana, L. A. Amoretti, R. J. Wright, S. Morjaria, M. Fenelus, M. S. Pessin, , J. B. Xavier

The paper identifies associations between gut bacteria and white blood cell dynamics in humans during recovery from hematopoietic cell transplantation.

bioRxiv · May 7, 2020 · PreprintMicrobiology