Extent of N-terminus exposure by altered long-range interactions of monomeric alpha-synuclein determines its aggregation propensity
A. D. Stephens, M. Zacharopoulou, R. Moons, G. Fusco, N. Seetaloo, A. Chiki, P. J. Hooper, I. Mela, H. A. Lashuel, J. J. Philips, A. De Simone, F. D. Sobott, G. S. Kaminski Schierle
This study investigates how calcium-induced conformational changes in monomeric alpha-synuclein affect N-terminus exposure and aggregation propensity, identifying sequence-specific conformational differences as key factors.
bioRxiv · Aug 20, 2019 · PreprintBiophysics