H. A. Lashuel

Label-free Identification of Protein Aggregates Using Deep Learning

This paper introduces LINA, a deep learning method for label-free identification of protein aggregates in living cells, showing that shorter polyglutamine repeats lead to larger aggregates.

O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology

This study shows that O-GlcNAc modification of α-Synuclein leads to amyloid fibrils with reduced seeding activity and pathology in Parkinson's disease models.

Investigating crosstalk among PTMs provides novel insight into the structural basis underlying the differential effects of Nt17 PTMs on mutant Httex1 aggregation

This study investigates how PTMs in Nt17 of mutant Httex1 affect aggregation, showing that oxM8 delays aggregation and that combinations with AcK6 inhibit fibrillization, with structural insights from spectroscopy and simulations.

Site-specific phosphorylation of Huntingtin exon 1 recombinant proteins enabled by the discovery of novel kinases

This paper introduces a method to produce site-specifically phosphorylated Httex1 proteins using novel kinases and SUMO-fusion purification, enabling further study of phosphorylation's role in Httex1 function.

Extent of N-terminus exposure by altered long-range interactions of monomeric alpha-synuclein determines its aggregation propensity

This study investigates how calcium-induced conformational changes in monomeric alpha-synuclein affect N-terminus exposure and aggregation propensity, identifying sequence-specific conformational differences as key factors.