J. J. Welch

Transient overdominance, coadaptation, and the fixability of heterosis

The paper examines how heterosis in hybrid species can arise from different genetic mechanisms and evaluates methods to distinguish between overdominance and coadaptation using introgression line data.

How does the mode of evolutionary divergence affect reproductive isolation?

This study uses a mathematical model to show that hybrid fitness depends on two properties of evolutionary change, and that different divergence histories can lead to similar hybrid outcomes.

Absence of Staphylococcus aureus in wild populations of fish supports a spillover hypothesis

This study investigates whether Staphylococcus aureus in wild fish results from spillover or adaptation, finding no S. aureus in wild trout or their environment, supporting spillover from other host populations.

The diverse effects of phenotypic dominance on hybrid fitness

This study examines how phenotypic dominance affects hybrid fitness using Fisher's geometric model, showing dominance often reduces fitness and can lead to outbreeding patterns and violations of Haldane's Rule.

Genome reduction is associated with bacterial pathogenicity across different scales of temporal and ecological divergence

The paper investigates whether genome reduction is linked to bacterial pathogenicity across different scales of divergence and finds it consistently associated with reduced genome size in pathogens.

How do species barriers decay? Concordance and local introgression in mosaic hybrid zones of mussels

The paper examines species barrier decay in mussels by analyzing introgression patterns and SNP concordance in hybrid zones.

A comprehensive portrait of antimicrobial resistance in the zoonotic pathogen Streptococcus suis

This study examines antimicrobial resistance in Streptococcus suis using MIC measurements and whole-genome sequencing, identifying resistance determinants and highlighting the complexity of resistance mechanisms.

The Geometry and Genetics of Hybridization

The paper develops a geometric framework to predict hybrid fitness by decomposing it into intrinsic and extrinsic factors, showing its applicability across population genetic regimes.

Replicated anthropogenic hybridisations reveal parallel patterns of admixture in marine mussels.

The paper studies hybridization patterns in marine mussels caused by human activity, finding repeatable genetic shifts and admixture patterns influenced by genetic background.

Structure of herpes simplex virus pUL7:pUL51, a conserved complex required for efficient herpesvirus assembly

This paper solves the structure of the HSV-1 pUL7:pUL51 complex, showing its conservation across herpesviruses and its potential role in membrane remodeling during virus assembly.

The distribution of epistasis on simple fitness landscapes

The paper analyzes epistasis in yeast snoRNA mutant data using simple fitness landscape models, finding that epistasis has limited impact on evolutionary dynamics.

Wolbachia, Cardinium and climate: an analysis of global data

The paper analyzes global data on Wolbachia and Cardinium infections in arthropods to assess the impact of temperature on their prevalence across different climates.

The divergence history of European blue mussel species reconstructed from Approximate Bayesian Computation: the effects of sequencing techniques and sampling strategies

This study uses Approximate Bayesian Computation to reconstruct the divergence history of European blue mussels, showing that binning strategies in site frequency spectra significantly affect results and that complex gene flow models are preferred.

Coadapted genomes and selection on hybrids: Fisher’s geometric model explains a variety of empirical patterns

The paper develops a fitness landscape model to explain hybridization patterns across species, supported by genomic data from multiple organisms.