Author

C. M. Crump

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Research Focus:host-pathogen & immune response· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 2 Assay:fluorescence / live-cell microscopy· 2 Assay:imaging· 2 Approach:microscopy & imaging analysis· 2

Frequent Co-Authors

S. C. Graham· 6 shared V. Connor· 6 shared D. I. Svergun· 3 shared C. F. Kaminski· 2 shared C. M. Jeffries· 2 shared H. G. Barrow· 2 shared J. E. Deane· 2 shared J. Muenzner· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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6 shared papersMicrobiology

S. C. Graham

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Applying 3D correlative structured illumination microscopy and X-ray tomography to characterise herpes simplex virus-1 morphogenesis

K. L. Nahas, V. Connor, K. J. Wijesinghe, H. G. Barrow, I. M. Dobbie, M. Harkiolaki, S. C. Graham, C. M. Crump

This study uses 3D correlative fluorescence and X-ray tomography to analyze HSV-1 mutants, revealing roles of viral proteins in morphogenesis and showing envelopment occurs via budding.

bioRxiv · Mar 13, 2024Microbiology

Genome-wide CRISPR/Cas9 screen identifies MAT2A as a critical host factor for BK Polyomavirus

L. Caller, S. Ho, K. Brown, L. Dupont, T. Zaletel, R. Beale, P. J. Lehner, C. M. Crump

The paper identifies MAT2A as a critical host factor for BKPyV infection through a CRISPR/Cas9 screen and shows a small molecule inhibitor of MAT2A is a potent antiviral drug.

bioRxiv · Oct 20, 2023 · PreprintMicrobiology

Herpes simplex virus 1 protein pUL21 stimulates cellular ceramide transport by activating CERT

T. H. Benedyk, V. Connor, E. R. Caroe, M. Shamin, D. I. Svergun, J. E. Deane, C. M. Jeffries, C. M. Crump, S. C. Graham

This paper shows HSV-1 protein pUL21 activates CERT to increase ceramide to sphingomyelin conversion, but does not affect virus replication or spread.

bioRxiv · Jun 1, 2022Microbiology

Near-native state imaging by cryo-soft-X-ray tomography reveals remodelling of multiple cellular organelles during HSV-1 infection

K. L. Nahas, V. Connor, K. M. Scherer, C. F. Kaminski, M. Harkiolaki, C. M. Crump, S. C. Graham

This study uses cryo-soft-X-ray tomography to image HSV-1 infected cells in near-native state, revealing morphological changes in organelles like mitochondria and cytoplasmic vesicles.

bioRxiv · Oct 11, 2021Microbiology

pUL21 is a viral phosphatase adaptor that promotes herpes simplex virus replication and spread

T. H. Benedyk, J. Muenzner, V. Connor, Y. Han, K. Brown, K. J. Wijesinghe, Y. Zhuang, S. Colaco, G. A. Stoll, O. S. Tutt, S. Svobodova, D. I. Svergun, N. A. Bryant, J. E. Deane, A. E. Firth, , S. C. Graham

This study identifies pUL21 as a viral phosphatase adaptor that promotes HSV-1 replication and spread by directing dephosphorylation and antagonizing pUS3 kinase activity.

bioRxiv · Apr 13, 2021Microbiology

Spatiotemporal analysis of host cell modification during herpes simplex virus 1 replication

K. M. Scherer, J. D. Manton, T. K. Soh, L. Mascheroni, V. Connor, C. M. Crump, C. F. Kaminski

This study uses a recombinant reporter virus to analyze the spatiotemporal dynamics of host cell modifications during herpes simplex virus 1 replication.

bioRxiv · Dec 22, 2019 · PreprintMicrobiology

Structure of herpes simplex virus pUL7:pUL51, a conserved complex required for efficient herpesvirus assembly

B. G. Butt, D. J. Owen, C. Jeffries, L. Ivanova, J. W. Houghton, M. F. Ahmed, R. Antrobus, D. I. Svergun, J. J. Welch, C. M. Crump, S. C. Graham

This paper solves the structure of the HSV-1 pUL7:pUL51 complex, showing its conservation across herpesviruses and its potential role in membrane remodeling during virus assembly.

bioRxiv · Oct 18, 2019Microbiology

Herpes simplex virus-1 pUL56 degrades GOPC to alter the plasma membrane proteome

T. K. Soh, C. T. R. Davies, J. Muenzner, V. Connor, C. R. Bouton, H. G. Barrow, C. Smith, E. Emmott, R. Antrobus, S. C. Graham, M. P. Weekes, C. M. Crump

This study identifies HSV-1 pUL56 as a protein that degrades GOPC, altering the plasma membrane proteome by affecting signaling receptors.

bioRxiv · Aug 8, 2019Microbiology