Natural IgA and TNFRSF13B polymorphism: a double edged sword fueling balancing selection
J. L. Platt, M. G. de Mattos Barbosa, D. Huynh, A. R. Leferts, J. Katta, C. Kharas, P. Freddolino, C. M. Bassis, C. E. Wobus, R. Geha, R. J. Bram, G. Nunez, N. Kamada, M. Cascalho
The paper investigates how a dominant-negative variant of TNFRSF13B confers resistance to enteric pathogens by reducing natural IgA, suggesting balancing selection due to its dual role in immunity and pathogenesis.
bioRxiv · Jan 29, 2021 · PreprintImmunology