Author

G. Nunez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 4 Approach:experimental assay· 3 Organism:mouse· 3 Organism:human· 1 Organism:non-human primate· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

N. Kamada· 2 shared A. R. Leferts· 1 shared A. Taher· 1 shared C. E. Wobus· 1 shared C. Gao· 1 shared C. Gaspar· 1 shared C. J. Alteri· 1 shared C. Kharas· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMicrobiology

N. Kamada

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Author profile →

4 papers

Recent·Most cited

Site-specific adaptation mechanisms of an oral pathobiont in the oral and gut mucosae

Y. Guo, S. Kitamoto, G. Caballero-Flores, D. Watanabe, K. Sugihara, G. Nunez, C. J. Alteri, N. Inohara, N. Kamada

This study identifies adaptation mechanisms of Klebsiella aerogenes in oral and gut mucosae, revealing distinct gene usage for colonization in each environment.

bioRxiv · Jan 13, 2022 · PreprintMicrobiology

Natural IgA and TNFRSF13B polymorphism: a double edged sword fueling balancing selection

J. L. Platt, M. G. de Mattos Barbosa, D. Huynh, A. R. Leferts, J. Katta, C. Kharas, P. Freddolino, C. M. Bassis, C. E. Wobus, R. Geha, R. J. Bram, G. Nunez, N. Kamada, M. Cascalho

The paper investigates how a dominant-negative variant of TNFRSF13B confers resistance to enteric pathogens by reducing natural IgA, suggesting balancing selection due to its dual role in immunity and pathogenesis.

bioRxiv · Jan 29, 2021 · PreprintImmunology

G-CSF SECRETED BY EPIGENETICALLY REPROGRAMMED MUTANT IDH1 GLIOMA STEM CELLS REVERSES THE MYELOID CELLS'-MEDIATED IMMUNOSUPPRESSIVE TUMOR MICROENVIRONMENT

M. S. Alghamri, R. Avvari, R. Thalla, N. Kamran, L. Zhang, M. Ventosa, A. Taher, S. Faisal, F. Nunez, M. Garcia-Fabiani, S. Haase, S. Carney, D. Orringer, S. Hervey-Jumper, J. Heth, , M. G. Castro

The paper shows that mIDH1 glioma stem cells secrete G-CSF, which reprograms myeloid cells to become non-immunosuppressive, altering the tumor microenvironment.

bioRxiv · Jul 22, 2020 · PreprintCancer Biology

Oral administration of an anti-CfaE secretory IgA antibody protects against Enterotoxigenic Escherichia coli diarrheal disease in a non-human primate model

M. Stoppato, C. Gaspar, J. Regeimbal, G. Nunez, s. giuntini, M. A. Gawron, J. R. Pondish, J. C. Martin, M. Schneider, Z. A. Schiller, M. Klempner, L. A. Cavacini, Y. Wang

This study evaluates the efficacy of secretory IgA2 and dimeric IgA2 antibodies against ETEC in a non-human primate model, finding that oral SIgA2 significantly reduced diarrheal attack rates.

bioRxiv · Aug 28, 2019Immunology