D. Huynh

Individualized AI-driven Neuromodulation Selectively Enhances and Reorganizes Human Tongue Sensorimotor Networks.

This paper introduces an AI-driven neuromodulation platform that enhances and reorganizes human tongue sensorimotor networks by targeting individual network architecture.

Individualized AI-driven neuromodulation enhances tongue motor and sensory control networks: a platform for neurorehabilitation in cancer survivors and patients with neurodegenerative disease.

This paper introduces an AI-driven fMRI neuromodulation platform that enhances sensorimotor control networks in healthy participants, showing improved signal strength and network expansion with functional persistence.

Effective in vivo binding energy landscape illustrates kinetic stability of RBPJ-DNA binding

The paper investigates RBPJ-DNA binding kinetics and cofactor interactions, finding that kinetic stability, not thermodynamic, governs target site specificity and that mutations affect both association and dissociation rates.

Systematic characterization of therapeutic vulnerabilities in Multiple Myeloma with Amp1q reveals increased sensitivity to the combination of MCL1 and PI3K inhibitors

Single immunization with recombinant ACAM2000 vaccinia viruses expressing the spike and the nucleocapsid proteins protect hamsters against SARS-CoV-2 caused clinical disease

This study shows that a single immunization with a vaccinia virus expressing both SARS-CoV-2 spike and nucleocapsid proteins protects hamsters better than expressing either protein alone.

Implications of Spike-glycoprotein processing at S1/S2 by Furin, at S2' by Furin and/or TMPRSS2 and shedding of ACE2: cell-to-cell fusion, cell entry and infectivity of SARS-CoV-2

The paper discusses the implications of spike-glycoprotein processing by Furin and TMPRSS2 on SARS-CoV-2 infectivity and cell entry, but the manuscript has been withdrawn.

Natural IgA and TNFRSF13B polymorphism: a double edged sword fueling balancing selection

The paper investigates how a dominant-negative variant of TNFRSF13B confers resistance to enteric pathogens by reducing natural IgA, suggesting balancing selection due to its dual role in immunity and pathogenesis.

SARS-CoV-2 spike-glycoprotein processing at S1/S2 and S2' and shedding of the ACE2 viral receptor: roles of Furin and TMPRSS2 and implications for viral infectivity and cell-to-cell fusion

This study investigates the roles of Furin and TMPRSS2 in SARS-CoV-2 spike protein processing and viral entry, showing their synergistic effects and suggesting combined inhibitors as antivirals.

A 3.8 A Resolution Cryo-EM Structure of a Small Protein Bound to a Modular Imaging Scaffold

This paper demonstrates a method to image small proteins using cryo-EM by binding them to a modular scaffold, achieving 3.8 Å resolution for a 26 kDa protein.