Author

J. Kesseli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 4

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Approach:statistical model· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

M. Nykter· 4 shared E. Afyounian· 3 shared A. Urbanucci· 2 shared K. J. Rautajoki· 2 shared L. Latonen· 2 shared T. L. J. Tammela· 2 shared T. Visakorpi· 2 shared A. Erickson· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

M. Nykter

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4 papers

Recent·Most cited

Immunosuppression in the prostate tumor microenvironment is tied to androgen deprivation therapy-resistant club-like cells

A. Kiviaho, S. K. Eerola, H. M. L. Kallio, M. K. Andersen, X. Spotbeen, A. Giesen, C. T. A. Parker, S. Taavitsainen, O. Hantula, M. Marttinen, I. Hermelo, M. Ismail, E. Midtbust, M. Wess, W. Devlies, , M. Nykter

The paper identifies club-like cells in the prostate tumor microenvironment that contribute to androgen deprivation therapy resistance through immune suppression.

bioRxiv · Mar 25, 2024 · PreprintCancer Biology

Spatial cumulant models enable spatially informed treatment strategies and analysis of local interactions in cancer systems

S. Hamis, P. Somervuo, J. A. Agren, D. S. Tadele, J. Kesseli, J. G. Scott, M. Nykter, P. Gerlee, D. Finkelshtein, O. Ovaskainen

This paper introduces spatial cumulant models to analyze and improve treatment strategies for cancer cell populations modeled as spatio-temporal point processes.

bioRxiv · May 7, 2022Cancer Biology

Aberrant DNA methylation distorts developmental trajectories in atypical teratoid/rhabdoid tumors

M. Pekkarinen, K. Nordfors, J. Uusi-Makela, V. Kytola, M. Rauhala, H. Urhonen, S. Hayrynen, E. Afyounian, O. Yli-Harja, W. Zhang, P. Helen, O. Lohi, H. Haapasalo, J. Haapasalo, M. Nykter, , K. J. Rautajoki

This study identifies aberrant DNA methylation patterns in AT/RTs that disrupt neural development and contribute to tumor malignancy.

bioRxiv · Mar 14, 2022Cancer Biology

Chromatin accessibility analysis uncovers regulatory element landscape in prostate cancer progression

J. Uusi-Mäkelä, E. Afyounian, F. Tabaro, T. Häkkinen, A. Lussana, A. Shcherban, M. Annala, R. Nurminen, K. Kivinummi, T. L. J. Tammela, A. Urbanucci, L. Latonen, J. Kesseli, K. J. Granberg, T. Visakorpi, M. Nykter

The paper analyzes chromatin accessibility in prostate cancer stages to identify regulatory elements and their role in gene expression changes during disease progression.

bioRxiv · Sep 8, 2020 · PreprintCancer Biology