Author

O. Lohi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:gene regulatory network inference· 2 Approach:machine learning (classical)· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

M. Heinaniemi· 4 shared J. Mehtonen· 3 shared P. Polonen· 3 shared A. Malyukova· 2 shared M. Lahnalampi· 2 shared M. Nykter· 2 shared O. Sangfelt· 2 shared S. Teppo· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersCancer Biology

M. Heinaniemi

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Sequential drug treatment targeting cell cycle and cell fate regulatory programs blocks non-genetic cancer evolution in acute lymphoblastic leukemia

A. Malyukova, M. Lahnalampi, T. Falques-Costa, P. Polonen, M. Sipola, J. Mehtonen, S. Teppo, J. Viiliainen, O. Lohi, A. Hagstrom-Andersson, M. Heinaniemi, O. Sangfelt

bioRxiv · Mar 27, 2023 · PreprintCancer Biology

Aberrant DNA methylation distorts developmental trajectories in atypical teratoid/rhabdoid tumors

M. Pekkarinen, K. Nordfors, J. Uusi-Makela, V. Kytola, M. Rauhala, H. Urhonen, S. Hayrynen, E. Afyounian, O. Yli-Harja, W. Zhang, P. Helen, O. Lohi, H. Haapasalo, J. Haapasalo, M. Nykter, , K. J. Rautajoki

This study identifies aberrant DNA methylation patterns in AT/RTs that disrupt neural development and contribute to tumor malignancy.

bioRxiv · Mar 14, 2022Cancer Biology

Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1 positive pediatric leukemia identifies drug-targetable transcription factor activities

J. Mehtonen, S. Teppo, M. Lahnalampi, A. Kokko, R. Kaukonen, L. Oksa, M. Bouvy-Liivrand, A. Malyukova, S. Laukkanen, P. I. Makinen, S. Rounioja, P. Ruusuvuori, O. Sangfelt, R. Lund, T. Lonnberg, , M. Heinaniemi

This study uses scRNA-seq to analyze B-lymphoid differentiation and leukemic cell states in ETV6-RUNX1-positive pediatric leukemia, identifying drug-targetable transcription factor activities.

bioRxiv · May 27, 2020Cancer Biology

Signaling input from divergent pathways subverts malignant B-cell transformation

L. N. Chan, M. A. Murakami, M. E. Robinson, R. Caeser, T. Sadras, J. Lee, K. N. Cosgun, K. Kume, V. Khairnar, G. Xiao, M. Ahmed, E. Aghania, G. Deb, C. Hurtz, S. Shojaee, , M. Muschen

This study shows that malignant B-cell transformation requires convergence on a single oncogenic pathway, while divergent pathways can subvert transformation and are targets for new therapeutic strategies.

bioRxiv · Mar 12, 2020Cancer Biology

Immunogenomic landscape of hematological malignancies

O. Dufva, P. Polonen, O. Bruck, M. Keranen, J. Mehtonen, A. Kumar, C. Heckman, S. Siitonen, K. Granberg, S.-K. Leivonen, L. Meriranta, S. Leppa, M. Nykter, O. Lohi, M. Heinaniemi, S. Mustjoki

This study links immunological features to cancer subtypes, genetic alterations, and patient survival in hematological malignancies using integrated genomic and transcriptomic data.

bioRxiv · Apr 26, 2019Immunology