M. Nykter

Immunosuppression in the prostate tumor microenvironment is tied to androgen deprivation therapy-resistant club-like cells

The paper identifies club-like cells in the prostate tumor microenvironment that contribute to androgen deprivation therapy resistance through immune suppression.

ABI1 regulates transcriptional activity of Androgen Receptor by novel DNA and AR binding mechanism

This paper identifies ABI1 as an epigenetic regulator of transcriptional homeostasis in AR-driven cancers through novel DNA and AR binding mechanisms.

RAS and PP2A activities converge on epigenetic gene regulation

This study identifies epigenetic gene regulation as a convergence point for RAS hyperactivity and PP2A inhibition in cancer, showing their co-regulation of key chromatin modifiers and oncogenic transcription.

Spatial cumulant models enable spatially informed treatment strategies and analysis of local interactions in cancer systems

This paper introduces spatial cumulant models to analyze and improve treatment strategies for cancer cell populations modeled as spatio-temporal point processes.

Aberrant DNA methylation distorts developmental trajectories in atypical teratoid/rhabdoid tumors

This study identifies aberrant DNA methylation patterns in AT/RTs that disrupt neural development and contribute to tumor malignancy.

Single-cell ATAC and RNA sequencing reveal pre-existing and persistent subpopulations of cells associated with relapse of prostate cancer

The paper uses single-cell ATAC and RNA sequencing to identify pre-existing and treatment-persistent stem-like cell subpopulations in prostate cancer models that predict treatment response.

Chromatin accessibility analysis uncovers regulatory element landscape in prostate cancer progression

The paper analyzes chromatin accessibility in prostate cancer stages to identify regulatory elements and their role in gene expression changes during disease progression.

Prostate Specific Membrane Antigen expression in the vasculature of primary lung carcinomas associates with faster metastatic dissemination to brain

The paper links PSMA vascular expression in primary lung carcinomas to faster brain metastasis and poorer survival.

Immunogenomic landscape of hematological malignancies

This study links immunological features to cancer subtypes, genetic alterations, and patient survival in hematological malignancies using integrated genomic and transcriptomic data.