Author

J. Konvalinka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. Fossoul· 1 shared B. L. Lee· 1 shared C. E. Stivala· 1 shared D. Demon· 1 shared E. Krüger· 1 shared F. Sedlak· 1 shared F. Van Hauwermeiren· 1 shared I. B. Stowe· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

A. Fossoul

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2 papers

Recent·Most cited

DDI2 protease activity controls embryonic development and inflammation via TCF11/NRF1

M. Siva, S. Haberecht-Müller, M. Prochazkova, J. Prochazka, F. Sedlak, K. Chawengsaksophak, P. Kasparek, R. Sedlacek, J. Konvalinka, E. Krüger, K. Grantz Saskova

This study shows that DDI2 protease is essential for embryonic development and immune balance by regulating TCF11/NRF1 and proteostasis.

bioRxiv · Dec 16, 2020Cell Biology

MCC950/CRID3 potently targets the NACHT domain of wildtype NLRP3 but not disease-associated mutants for inflammasome inhibition

L. Vande Walle, I. B. Stowe, P. Sacha, B. L. Lee, D. Demon, A. Fossoul, F. Van Hauwermeiren, P. H. V. Saavedra, P. Simon, V. Subrt, L. Kostka, C. E. Stivala, V. C. Pham, S. T. Staben, S. Yamazoe, , M. Lamkanfi

This study identifies the NACHT domain of wildtype NLRP3 as the target of MCC950/CRID3, showing it inhibits inflammasome activity but not CAPS-associated mutants.

bioRxiv · May 11, 2019Immunology