Author

S. T. Staben

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Dey· 1 shared A. Fossoul· 1 shared A. Olivero· 1 shared B. L. Lee· 1 shared C. E. Stivala· 1 shared D. Demon· 1 shared D. Kirkpatrick· 1 shared D. Sampath· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. Dey

Mutual co-authors in cluster

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2 papers

Recent·Most cited

RTK-dependent inducible degradation of mutant PI3K alpha drives GDC-0077 (Inavolisib) efficacy

K. Song, K. Edgar, E. Hanan, M. Hafner, J. Oeh, M. Merchant, D. Sampath, M. Nannini, R. Hong, L. Phu, W. Forrest, E. Stawiski, S. schmidt, N. Endres, J. Guan, , L. Friedman

The paper shows that GDC-0077 and taselisib degrade mutant PI3K alpha via HER2-dependent mechanisms, enhancing efficacy in PIK3CA-mutant breast cancer.

bioRxiv · May 12, 2021Cancer Biology

MCC950/CRID3 potently targets the NACHT domain of wildtype NLRP3 but not disease-associated mutants for inflammasome inhibition

L. Vande Walle, I. B. Stowe, P. Sacha, B. L. Lee, D. Demon, A. Fossoul, F. Van Hauwermeiren, P. H. V. Saavedra, P. Simon, V. Subrt, L. Kostka, C. E. Stivala, V. C. Pham, S. T. Staben, S. Yamazoe, , M. Lamkanfi

This study identifies the NACHT domain of wildtype NLRP3 as the target of MCC950/CRID3, showing it inhibits inflammasome activity but not CAPS-associated mutants.

bioRxiv · May 11, 2019Immunology