Author

B. L. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. A. DeLaney· 1 shared A. C. Murthy· 1 shared A. Chesi· 1 shared A. Fossoul· 1 shared A. M. Gleixner· 1 shared A. Smirnov· 1 shared A. W. Roberts· 1 shared B. C. Schaefer· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperImmunology

A. A. DeLaney

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains

L. Guo, J. R. Mann, J. C. Mauna, K. E. Copley, H. Wang, J. D. Rubien, H. M. Odeh, J. Lin, B. L. Lee, L. Ganser, E. Robinson, K. M. Kim, A. C. Murthy, T. Paul, B. Portz, , J. Shorter

The paper identifies short RNAs that prevent and reverse pathological fibrillization of RNA-binding proteins like FUS and TDP-43, showing therapeutic potential for ALS/FTD.

bioRxiv · Sep 4, 2023Biochemistry

Genetic targeting of Card19 is linked to disrupted Ninj1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection

E. Bjanes, R. G. Sillas, R. Matsuda, B. Demarco, T. Fettrelet, A. A. DeLaney, O. S. Kornfeld, B. L. Lee, E. M. Rodriguez Lopez, D. Grubaugh, M. A. Wynosky-Dolfi, N. H. Philip, E. Krespan, D. Tovar, L. Joannas, , I. E. Brodsky

This study shows that genetic targeting of Card19 disrupts Ninj1 expression, impairs macrophage cell lysis, and increases susceptibility to Yersinia infection.

bioRxiv · Mar 19, 2021 · PreprintImmunology

MCC950/CRID3 potently targets the NACHT domain of wildtype NLRP3 but not disease-associated mutants for inflammasome inhibition

L. Vande Walle, I. B. Stowe, P. Sacha, B. L. Lee, D. Demon, A. Fossoul, F. Van Hauwermeiren, P. H. V. Saavedra, P. Simon, V. Subrt, L. Kostka, C. E. Stivala, V. C. Pham, S. T. Staben, S. Yamazoe, , M. Lamkanfi

This study identifies the NACHT domain of wildtype NLRP3 as the target of MCC950/CRID3, showing it inhibits inflammasome activity but not CAPS-associated mutants.

bioRxiv · May 11, 2019Immunology

Resident Macrophages are Locally Programmed for Silent Clearance of Apoptotic Cells

A. W. Roberts, B. L. Lee, J. Deguine, S. John, M. Shlomchik, G. M. Barton

The paper identifies macrophages that silently clear apoptotic cells by expressing AC receptors and limiting nucleic acid responses, showing that tissue cues program this behavior.

bioRxiv · Jun 24, 2017Immunology