Mitotic progression following DNA damage enables pattern recognition within micronuclei
S. M. Harding, J. L. Benci, J. Irianto, D. E. Discher, A. J. Minn, R. A. Greenberg
The paper shows that mitotic progression after DNA damage forms micronuclei, which activate inflammatory signaling and are critical for abscopal tumor regression in combination with immune checkpoint blockade.
bioRxiv · Jun 27, 2017Cancer Biology