Author

D. E. Discher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2

Frequent Co-Authors

J. Irianto· 4 shared L. J. Dooling· 3 shared M. Vashisth· 3 shared B. H. Hayes· 2 shared C. R. Pfeifer· 2 shared J. C. Andrechak· 2 shared K. Zhu· 2 shared R. A. Greenberg· 2 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersCell Biology

J. Irianto

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Author profile →

6 papers

Recent·Most cited

Titrating CD47 by mismatch CRISPRi reveals incomplete repression can eliminate IgG-opsonized tumors but CD47 heterogeneity limits induction of anti-tumor IgG

B. H. Hayes, H. Zhu, J. C. Andrechak, D. E. Discher

This study uses CRISPRi to titrate CD47 in melanoma cells, showing that incomplete repression can eliminate opsonized tumors but CD47 heterogeneity limits anti-tumor IgG induction.

bioRxiv · Sep 27, 2022 · PreprintCancer Biology

Cooperative phagocytosis underlies macrophage immunotherapy of solid tumours and initiates a broad anti-tumour IgG response

J. C. Andrechak, L. J. Dooling, B. H. Hayes, S. Kadu, W. Zhang, R. Pan, M. Vashisth, J. Irianto, C. M. Alvey, D. E. Discher

This study shows engineered macrophages using cooperative phagocytosis eliminate solid tumours and induce anti-tumour IgG, improving immunotherapy outcomes.

bioRxiv · Jan 1, 2022Bioengineering

Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate

C. R. Pfeifer, M. P. Tobin, S. Cho, M. Vashisth, L. J. Dooling, L. L. Vasquez, E. G. Ricci-De Lucca, K. T. Simon, D. E. Discher

The paper shows that high nuclear curvature causes lamin-B dilution and rupture, with lamin-A also contributing under high strain rates, suggesting a viscoplastic response to mechanical stress.

bioRxiv · Oct 13, 2021Biophysics

Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell cycle arrest

S. Cho, M. Vashisth, A. Abbas, S. Majkut, K. Vogel, Y. Xia, I. L. Ivanovska, J. Irianto, M. Tewari, K. Zhu, E. D. Tichy, F. Mourkioti, H.-Y. Tang, R. Greenberg, B. L. Prosser, D. E. Discher

The paper shows that lamin-A stabilizes the genome by protecting against nuclear rupture, DNA damage, and cell cycle arrest under mechanical stress.

bioRxiv · Mar 20, 2019Cell Biology

Rescue of DNA damage in cells after constricted migration reveals bimodal mechano-regulation of cell cycle

Y. Xia, C. R. Pfeifer, K. Zhu, J. Irianto, D. Liu, K. Pannell, E. J. Chen, L. J. Dooling, R. A. Greenberg, D. E. Discher

The paper investigates DNA damage and cell cycle effects during constricted cell migration, finding a bimodal relationship between DNA damage and cell cycle regulation.

bioRxiv · Dec 30, 2018Cell Biology

Mitotic progression following DNA damage enables pattern recognition within micronuclei

S. M. Harding, J. L. Benci, J. Irianto, D. E. Discher, A. J. Minn, R. A. Greenberg

The paper shows that mitotic progression after DNA damage forms micronuclei, which activate inflammatory signaling and are critical for abscopal tumor regression in combination with immune checkpoint blockade.

bioRxiv · Jun 27, 2017Cancer Biology