Author

J. Irianto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Cell Biology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 7 Research Focus:cell type annotation· 4 Research Focus:chromatin & epigenetic regulation· 4 Assay:bulk RNA-seq· 3 Research Focus:cell signaling & trafficking· 3 Research Focus:differential expression· 3 Organism:mouse· 3

Frequent Co-Authors

D. E. Discher· 4 shared Y. Xia· 4 shared G. Xie· 3 shared L. J. Dooling· 3 shared M. Vashisth· 3 shared Y. J. Wang· 3 shared B. Hayes· 2 shared D. Discher· 2 shared

Activity by Year

2017-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersCell Biology

D. E. Discher

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Confinement with Myosin-II suppression increases heritable loss of chromosomes, using live-cell ChReporters

B. Hayes, P. Zhu, M. Wang, C. Pfeifer, Y. Xia, S. Phan, J. Andrechak, J. Du, M. Tobin, A. Anlas, L. Dooling, J. Irianto, M. Lampson, D. Discher

The paper uses live-cell ChReporters to show that Myosin-II suppression in confined mitosis increases heritable chromosome loss, independent of spindle assembly checkpoint in 3D and 2D.

bioRxiv · Feb 25, 2023 · PreprintCell Biology

Differential modulation of cellular phenotype and drug sensitivity by extracellular matrix proteins in primary and metastatic pancreatic cancer cells

O. H. Usman, S. Kumar, R. R. Walker, G. Xie, H. Sumajit, A. R. Jalil, S. Ramakrishnan, L. J. Dooling, Y. J. Wang, J. Irianto

This study shows that ECM proteins differentially affect morphology, proliferation, and drug sensitivity in primary but not metastatic pancreatic cancer cells, with transcriptomic changes in primary cells.

bioRxiv · Nov 11, 2022Cancer Biology

Phenotypic, genomic, and transcriptomic heterogeneity in a pancreatic cancer cell line

G. Xie, L. Zhang, O. H. Usman, S. Kumar, C. Modak, D. Patel, M. Kavanaugh, X. Mallory, Y. J. Wang, J. Irianto

The paper characterizes phenotypic, genomic, and transcriptomic heterogeneity in MIA PaCa-2 pancreatic cancer cell clones, showing distinct traits and suggesting its use as a model for studying cancer heterogeneity.

bioRxiv · Nov 11, 2022Cancer Biology

Genomic heterogeneity in pancreatic cancer organoids and its stability with culture

O. Usman, L. Zhang, G. Xie, H. M. Kocher, C.-i. Hwang, Y. J. Wang, X. F. Mallory, J. Irianto

This study examines genomic heterogeneity and stability in pancreatic cancer organoids using single-cell whole-genome sequencing and transcriptomic analysis.

bioRxiv · Jul 3, 2022Cancer Biology

Cooperative phagocytosis underlies macrophage immunotherapy of solid tumours and initiates a broad anti-tumour IgG response

J. C. Andrechak, L. J. Dooling, B. H. Hayes, S. Kadu, W. Zhang, R. Pan, M. Vashisth, J. Irianto, C. M. Alvey, D. E. Discher

This study shows engineered macrophages using cooperative phagocytosis eliminate solid tumours and induce anti-tumour IgG, improving immunotherapy outcomes.

bioRxiv · Jan 1, 2022Bioengineering

Scaling concepts in 'omics: nuclear lamin-B scales with tumor growth and predicts poor prognosis, whereas fibrosis can be pro-survival

M. Vashisth, D. Discher, S. Cho, J. Irianto, Y. Xia, M. Wang, B. Hayes, F. Jafarpour, A. Liu, R. G. Wells

The paper identifies scaling relationships between genes in cancer data, finding LMNB1 correlates with poor prognosis while fibrosis markers predict better survival.

bioRxiv · Feb 25, 2021 · PreprintCancer Biology

Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell cycle arrest

S. Cho, M. Vashisth, A. Abbas, S. Majkut, K. Vogel, Y. Xia, I. L. Ivanovska, J. Irianto, M. Tewari, K. Zhu, E. D. Tichy, F. Mourkioti, H.-Y. Tang, R. Greenberg, B. L. Prosser, D. E. Discher

The paper shows that lamin-A stabilizes the genome by protecting against nuclear rupture, DNA damage, and cell cycle arrest under mechanical stress.

bioRxiv · Mar 20, 2019Cell Biology

Rescue of DNA damage in cells after constricted migration reveals bimodal mechano-regulation of cell cycle

Y. Xia, C. R. Pfeifer, K. Zhu, J. Irianto, D. Liu, K. Pannell, E. J. Chen, L. J. Dooling, R. A. Greenberg, D. E. Discher

The paper investigates DNA damage and cell cycle effects during constricted cell migration, finding a bimodal relationship between DNA damage and cell cycle regulation.

bioRxiv · Dec 30, 2018Cell Biology

Mitotic progression following DNA damage enables pattern recognition within micronuclei

S. M. Harding, J. L. Benci, J. Irianto, D. E. Discher, A. J. Minn, R. A. Greenberg

The paper shows that mitotic progression after DNA damage forms micronuclei, which activate inflammatory signaling and are critical for abscopal tumor regression in combination with immune checkpoint blockade.

bioRxiv · Jun 27, 2017Cancer Biology