Author

S. M. Harding

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Assay:DNA methylation· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

K. M. MacDonald· 3 shared A. J. Minn· 2 shared R. A. Greenberg· 2 shared A. V. Columbus· 1 shared C. Arrowsmith· 1 shared C. J. Bakkenist· 1 shared D. E. Discher· 1 shared D. Ivanov· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersCell Biology

K. M. MacDonald

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Author profile →

5 papers

Recent·Most cited

Deoxyuridine-rich cytoplasmic DNA antagonizes STING-dependent innate immune responses and sensitizes resistant tumors to anti-PD-L1 therapy

P. Pandya, F. P. Vendetti, J. A. El-Ghoubaira, S. Pathak, J. J. Deppas, R. E. Jones, A. V. Columbus, Y. Zhang, D. Ivanov, Z. Huang, K. M. MacDonald, S. M. Harding, R. Buj, K. M. Aird, J. H. Beumer, , C. J. Bakkenist

The paper shows that dU-rich cytoplasmic DNA inhibits STING-dependent immune responses and enhances anti-PD-L1 therapy efficacy in tumors.

bioRxiv · Apr 4, 2024 · PreprintCancer Biology

The proteomic landscape of genotoxic stress-induced micronuclei

K. M. MacDonald, S. Khan, T. M. Kislinger, S. M. Harding

The paper profiles the proteome of micronuclei, cytoplasm, and nuclei in human cells exposed to genotoxins, revealing distinct proteomic features and their implications for DNA damage and chromothripsis.

bioRxiv · Aug 27, 2023Cell Biology

cGAS recruitment to micronuclei is dictated by pre-existing nuclear chromatin status.

K. M. MacDonald, S. Nicholson-Puthenveedu, M. M. Tageldein, C. Arrowsmith, S. M. Harding

The paper shows that cGAS recruitment to micronuclei depends on pre-existing nuclear chromatin status, not just MN envelope rupture.

bioRxiv · Jan 13, 2022 · PreprintCell Biology

Cell cycle checkpoints cooperate to suppress DNA and RNA associated molecular pattern recognition and anti-tumor immune responses

R. A. Greenberg, J. Chen, S. M. Harding, N. Ramakrishnan, L. Tian, J. Benci, W. Li, A. J. Minn, I. Asangani

The paper shows that disrupting cell cycle checkpoints can restore DNA damage-induced inflammation and anti-tumor immune responses in cancer cells.

bioRxiv · Jun 24, 2020Cell Biology

Mitotic progression following DNA damage enables pattern recognition within micronuclei

S. M. Harding, J. L. Benci, J. Irianto, D. E. Discher, A. J. Minn, R. A. Greenberg

The paper shows that mitotic progression after DNA damage forms micronuclei, which activate inflammatory signaling and are critical for abscopal tumor regression in combination with immune checkpoint blockade.

bioRxiv · Jun 27, 2017Cancer Biology