Author

A. J. Minn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:CITE-seq· 1

Frequent Co-Authors

R. A. Greenberg· 2 shared S. M. Harding· 2 shared A. Ayyaz· 1 shared A. Chow· 1 shared A. J. Plodkowski· 1 shared A. J. Schoenfeld· 1 shared A. R. Daniel· 1 shared B. D. Greenbaum· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCell Biology

R. A. Greenberg

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Author profile →

5 papers

Recent·Most cited

p53 promotes revival stem cells in the regenerating intestine after severe radiation injury

C. Morral, A. Ayyaz, H.-C. Kuo, M. Fink, I. Verginadis, A. R. Daniel, D. N. Burner, L. M. Driver, S. Satow, S. Hasapis, R. Ghinnagow, L. Luo, Y. Ma, L. D. Attardi, C. Koumenis, , D. G. Kirsch

bioRxiv · Apr 27, 2023Cell Biology

Therapeutic Interruption of T Cell Development Generates High-Affinity T Cells That Escape Exhaustion and Improve Cancer Immunotherapy

E. Dhuey, O. Oldridge, R. Ravishankar, H. Dada, Y. Yu, M. S. Anderson, A. J. Minn

This study shows that interrupting central tolerance generates high-affinity T cells that avoid exhaustion and enhance cancer immunotherapy.

bioRxiv · Jan 19, 2022 · PreprintImmunology

Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer

D. Memon, H. Rizvi, G. Fromm, J. Lihm, A. J. Schoenfeld, J. L. Sauter, J. Luo, A. Chow, U. K. Bhanot, C. McCarthy, D. Ye, C. M. Vanderbilt, C. Liu, M. Abu-Akeel, A. J. Plodkowski, , M. D. Hellmann

This study characterizes clinical and molecular features of acquired resistance to PD-(L)1 blockade in NSCLC, identifying persistent inflammation and dysfunctional IFN signaling as key features.

bioRxiv · Jul 21, 2021Cancer Biology

Cell cycle checkpoints cooperate to suppress DNA and RNA associated molecular pattern recognition and anti-tumor immune responses

R. A. Greenberg, J. Chen, S. M. Harding, N. Ramakrishnan, L. Tian, J. Benci, W. Li, A. J. Minn, I. Asangani

The paper shows that disrupting cell cycle checkpoints can restore DNA damage-induced inflammation and anti-tumor immune responses in cancer cells.

bioRxiv · Jun 24, 2020Cell Biology

Mitotic progression following DNA damage enables pattern recognition within micronuclei

S. M. Harding, J. L. Benci, J. Irianto, D. E. Discher, A. J. Minn, R. A. Greenberg

The paper shows that mitotic progression after DNA damage forms micronuclei, which activate inflammatory signaling and are critical for abscopal tumor regression in combination with immune checkpoint blockade.

bioRxiv · Jun 27, 2017Cancer Biology