Author

J. L. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:contrastive learning· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

M. D. Disney· 2 shared S. Choudhary· 2 shared A. J. Angelbello· 1 shared A. J. Frank· 1 shared A. Liu· 1 shared A. S. Jun· 1 shared A. Taghavi· 1 shared C. A. Thornton· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

M. D. Disney

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

NMR structures of small molecules bound to a model of an RNA CUG repeat expansion

J. L. Chen, A. Taghavi, A. J. Frank, M. A. Fountain, S. Choudhary, S. Roy, J. L. Childs-Disney, M. D. Disney

The paper reports NMR structures of small molecules bound to an RNA CUG repeat expansion motif, revealing binding interactions and conformational changes that inform drug design.

bioRxiv · Jun 21, 2024Biochemistry

Design and fabrication of a low-cost microfluidic cartridge with integrated pressure-driven check valve for molecular diagnostics platforms

R. S. Downen, Q. Dong, J. L. Chen, Z. Li

The paper designs and tests a low-cost microfluidic cartridge with a pressure-driven check valve for molecular diagnostics, demonstrating fluid manipulation and integration with a benchtop LAMP system.

bioRxiv · Dec 29, 2022Bioengineering

Counterfactual Hypothesis Testing of Tumor Microenvironment Scenarios Through Semantic Image Synthesis

D. Li, J. L. Chen, Q. Ma, Y. Xie, A. Liu, J. Cheung, H. Gudjonson, T. Nawy, D. Pe'er, I. Pe'er

The paper introduces a generative model to test hypotheses about cell-cell interactions in tumor microenvironments using synthetic multiplexed images.

bioRxiv · Oct 27, 2020 · PreprintCancer Biology

A small molecule that binds an RNA repeat expansion stimulates its decay via the exosome complex

A. J. Angelbello, R. I. Benhamou, S. G. Rzuczek, S. Choudhary, Z. Tang, J. L. Chen, M. Roy, K. W. Wang, I. Yildirim, A. S. Jun, C. A. Thornton, M. D. Disney

A small molecule binds an RNA repeat expansion, reversing disease defects in DM1 and FECD by either disabling gain-of-function or stimulating exosome-mediated decay.

bioRxiv · May 11, 2020Cell Biology