Author

C. A. Thornton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

E. Yutuc· 2 shared W. J. Griffiths· 2 shared Y. Wang· 2 shared A. Culhane· 1 shared A. Dickson· 1 shared A. E. Carpenter· 1 shared A. Filby· 1 shared A. J. Angelbello· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersBiochemistry

E. Yutuc

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Combinatorial chloride and calcium channelopathy in myotonic dystrophy

L. A. Cisco, M. T. Sipple, K. M. Edwards, C. A. Thornton, J. D. Lueck

The paper shows that combining chloride and calcium channel dysfunction in mice worsens myotonic dystrophy symptoms, and calcium blockers can improve survival and function.

bioRxiv · May 29, 2023Physiology

Multi-omic spatial profiling reveals the unique virus-driven immune landscape of COVID-19 placentitis

M. Pugh, E. Fennel, C. I. Leahy, T. Perry, B. Hargitai, T. Marton, K. J. Hunter, G. Halford, H. O. Yilmaz, Z. Stamataki, G. Reynolds, H. J. Hill, B. E. Willcox, N. M. Steven, C. A. Thornton, , G. S. Taylor

The paper uses multi-omic spatial profiling to show that SARS-CoV-2 infection in the placenta leads to a distinct immune signature with PDL1-expressing macrophages and T-cell exclusion.

bioRxiv · Nov 14, 2022 · PreprintImmunology

HSD3B1 is an Oxysterol 3β-Hydroxysteroid Dehydrogenase in Human Placenta

A. Dickson, E. Yutuc, C. A. Thornton, J. E. Dunford, U. Oppermann, Y. Wang, W. J. Griffiths

The paper identifies HSD3B1 as an enzyme in human placenta that converts oxysterols into 3-oxo-4-ene derivatives, which are found in umbilical cord and maternal plasma.

bioRxiv · Apr 1, 2022Biochemistry

Identification of Unusual Oxysterols Biosynthesised in Human Pregnancy by Charge-Tagging and Liquid Chromatography - Mass Spectrometry

A. L. Dickson, E. Yutuc, C. A. Thornton, Y. Wang, W. J. Griffiths

This study identifies 20S-hydroxycholesterol and proposes a novel pathway for C27 bile acid synthesis in pregnancy-related fluids.

bioRxiv · Feb 7, 2022Biochemistry

Inter-laboratory automation of the in vitro micronucleus assay using imaging flow cytometry and deep learning

J. W. Wills, J. R. Verma, B. J. Rees, D. S. G. Harte, Q. Haxhiraj, C. M. Barnes, R. Barnes, M. A. Rodrigues, M. Doan, A. Filby, R. E. Hewitt, C. A. Thornton, J. G. Cronin, J. D. Kenny, R. Buckley, , P. Rees

This paper automates the in vitro micronucleus assay using imaging flow cytometry and deep learning, achieving high classification accuracy across laboratories.

bioRxiv · May 5, 2021Pharmacology & Toxicology

A small molecule that binds an RNA repeat expansion stimulates its decay via the exosome complex

A. J. Angelbello, R. I. Benhamou, S. G. Rzuczek, S. Choudhary, Z. Tang, J. L. Chen, M. Roy, K. W. Wang, I. Yildirim, A. S. Jun, C. A. Thornton, M. D. Disney

A small molecule binds an RNA repeat expansion, reversing disease defects in DM1 and FECD by either disabling gain-of-function or stimulating exosome-mediated decay.

bioRxiv · May 11, 2020Cell Biology