Regulation of Interorganellar Ca2+ Transfer and NFAT Activation by the Mitochondrial Ca2+ Uniporter
R. E. Yoast, S. M. Emrich, X. Zhang, P. Xin, V. Arige, T. Pathak, J. C. Benson, M. T. Johnson, N. Lakomski, N. Hempel, J. M. Han, G. Dupont, D. I. Yule, J. Sneyd, M. Trebak
This study investigates how mitochondrial Ca2+ uniporter (MCU) regulates interorganellar Ca2+ signaling and NFAT activation, showing that MCU-KO increases cytosolic Ca2+ despite reduced CRAC channel activity.
bioRxiv · Apr 7, 2021Cell Biology