Author

S. M. Emrich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 5 Research Focus:metabolism & bioenergetics· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

M. Trebak· 5 shared R. E. Yoast· 5 shared P. Xin· 4 shared M. T. Johnson· 3 shared N. Hempel· 3 shared T. Pathak· 3 shared X. Zhang· 3 shared D. I. Yule· 2 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersCancer Biology

M. Trebak

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Orai3 and Orai1 are essential for CRAC channel function and metabolic reprogramming in B cells

S. M. Emrich, R. E. Yoast, X. Zhang, A. J. Fike, Y.-H. Wang, K. N. Bricker, A. Tao, P. Xin, V. Walter, M. T. Johnson, T. Pathak, A. C. Straub, S. Feske, Z. Rahman, M. Trebak

This study shows Orai1 and Orai3 are essential for CRAC channel function and metabolic reprogramming in B cells, impacting proliferation, survival, and metabolic processes.

bioRxiv · May 6, 2022Immunology

Regulation of Interorganellar Ca2+ Transfer and NFAT Activation by the Mitochondrial Ca2+ Uniporter

R. E. Yoast, S. M. Emrich, X. Zhang, P. Xin, V. Arige, T. Pathak, J. C. Benson, M. T. Johnson, N. Lakomski, N. Hempel, J. M. Han, G. Dupont, D. I. Yule, J. Sneyd, M. Trebak

This study investigates how mitochondrial Ca2+ uniporter (MCU) regulates interorganellar Ca2+ signaling and NFAT activation, showing that MCU-KO increases cytosolic Ca2+ despite reduced CRAC channel activity.

bioRxiv · Apr 7, 2021Cell Biology

Omnitemporal choreographies of IP3R and all five STIM/Orai underlie the complexity of mammalian Ca2+ signaling

S. M. Emrich, R. E. Yoast, P. Xin, V. Arige, L. E. Wagner, N. Hempel, D. L. Gill, J. Sneyd, D. I. Yule, M. Trebak

This paper shows that all five STIM1/2 and Orai1/2/3 isoforms, along with IP3R, work together in a graded manner to ensure precise and diverse Ca2+ signaling in mammals.

bioRxiv · Oct 4, 2020Physiology

The lysosomal TRPML1 channel promotes breast cancer survival by supporting mitochondrial function and cellular metabolism

S. Almasi, B. E. Kennedy, R. E. Yoast, S. M. Emrich, M. Trebak, Y. El Hiani

This study shows TRPML1 promotes TNBC survival by supporting mitochondrial function and metabolism, and its inhibition enhances chemotherapy effectiveness.

bioRxiv · Sep 4, 2020 · PreprintCancer Biology

Colorectal adenocarcinomas downregulate the mitochondrial Na+/Ca2+ exchanger NCLX to drive metastatic spread

T. Pathak, M. Gueguinou, V. Walter, C. Delierneux, M. T. Johnson, X. Zhang, P. Xin, R. E. Yoast, S. M. Emrich, G. S. Yochum, I. Sekler, W. A. Koltun, D. L. Gill, N. Hempel, M. Trebak

This study shows that reduced NCLX expression in colorectal tumors leads to mtCa2+ overload, promoting metastasis and chemoresistance through mtROS/HIF1 signaling.

bioRxiv · May 7, 2020 · PreprintCancer Biology