Author

V. Arige

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Cell Biology· 2 Biophysics· 1

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Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 5 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Assay:electrophysiology· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

D. I. Yule· 6 shared L. E. Terry· 3 shared L. E. Wagner· 3 shared G. Fan· 2 shared I. I. Serysheva· 2 shared J. Sneyd· 2 shared M. R. Baker· 2 shared M. Trebak· 2 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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6 shared papersPhysiology

D. I. Yule

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6 papers

Recent·Most cited

Structural dynamics underlying gating and regulation in IP3R channel

G. Fan, M. R. Baker, L. E. Terry, V. Arige, M. Chen, A. Seryshev, M. L. Baker, S. J. Ludtke, D. I. Yule, I. I. Serysheva

The paper determines 3D structures of IP3R1 in two ligand-bound states using cryo-EM and identifies dynamic properties of key domains involved in ligand binding and channel gating.

bioRxiv · May 27, 2022Biophysics

Regulation of Store-Operated Ca2+ Entry by IP3 Receptors Independent of Their Ability to Release Ca2+

P. Chakraborty, B. K. Deb, V. Arige, T. Musthafa, S. Malik, D. I. Yule, C. W. Taylor, G. Hasan

The paper shows IP3Rs regulate neuronal SOCE through IP3 binding, independent of Ca2+ release, by enhancing STIM1-Orai1 association.

bioRxiv · Apr 12, 2022Cell Biology

Functional Determination of Calcium Binding Sites Required for the Activation of Inositol 1,4,5-trisphosphate receptors.

V. Arige, L. E. Terry, L. E. Wagner, M. R. Baker, G. Fan, I. I. Serysheva, D. I. Yule

This study identifies acidic residues in IP3Rs critical for Ca2+ binding and activation, showing their role in modulating channel activity and Ca2+ sensitivity.

bioRxiv · Mar 7, 2022Physiology

CREB regulates the expression of Type 1 Inositol 1,4,5-trisphosphate receptors

V. Arige, L. E. Terry, T. R. Knebel, L. E. Wagner, D. I. Yule

This study shows that CREB regulates IP3R1 expression and localization, affecting Ca2+ release and puffs.

bioRxiv · May 5, 2021Physiology

Regulation of Interorganellar Ca2+ Transfer and NFAT Activation by the Mitochondrial Ca2+ Uniporter

R. E. Yoast, S. M. Emrich, X. Zhang, P. Xin, V. Arige, T. Pathak, J. C. Benson, M. T. Johnson, N. Lakomski, N. Hempel, J. M. Han, G. Dupont, D. I. Yule, J. Sneyd, M. Trebak

This study investigates how mitochondrial Ca2+ uniporter (MCU) regulates interorganellar Ca2+ signaling and NFAT activation, showing that MCU-KO increases cytosolic Ca2+ despite reduced CRAC channel activity.

bioRxiv · Apr 7, 2021Cell Biology

Omnitemporal choreographies of IP3R and all five STIM/Orai underlie the complexity of mammalian Ca2+ signaling

S. M. Emrich, R. E. Yoast, P. Xin, V. Arige, L. E. Wagner, N. Hempel, D. L. Gill, J. Sneyd, D. I. Yule, M. Trebak

This paper shows that all five STIM1/2 and Orai1/2/3 isoforms, along with IP3R, work together in a graded manner to ensure precise and diverse Ca2+ signaling in mammals.

bioRxiv · Oct 4, 2020Physiology