Author

M. Trebak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Physiology· 3 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:cell signaling & trafficking· 8 Research Focus:cancer & tumor microenvironment· 5 Organism:human· 5 Research Focus:metabolism & bioenergetics· 4 Organism:mouse· 4 Assay:proteomics· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

M. T. Johnson· 5 shared N. Hempel· 5 shared P. Xin· 5 shared R. E. Yoast· 5 shared S. M. Emrich· 5 shared T. Pathak· 5 shared V. Walter· 4 shared X. Zhang· 4 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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5 shared papersCancer Biology

M. T. Johnson

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway

T. Pathak, J. C. Benson, M. T. Johnson, P. Xin, A. E. Abdelnaby, V. Walter, W. A. Kultun, G. S. Yochum, N. Hempel, M. Trebak

This study shows that loss of STIM2 in colorectal cancer promotes tumor growth and metastasis through metabolic reprogramming and activation of the PERK-ATF4 ER stress pathway.

bioRxiv · Oct 2, 2023 · PreprintCancer Biology

Alternative splice variants of the mitochondrial fission protein DNM1L/Drp1 regulate mitochondrial dynamics and cell fate in ovarian cancer.

Z. Javed, D. H. Shin, W. Pan, S. R. White, Y. S. Kim, A. T. Elhaw, S. Kamlapurkar, Y.-Y. Cheng, J. C. Benson, A. E. Abdelnaby, R. Phaeton, H.-G. Wang, S. Yang, M. L. G. Sullivan, C. St. Croix, , N. Hempel

This study identifies an alternative splice variant of Drp1 in ovarian cancer that promotes metastasis and chemoresistance by altering mitochondrial dynamics.

bioRxiv · Sep 20, 2023Cancer Biology

Orai3 and Orai1 are essential for CRAC channel function and metabolic reprogramming in B cells

S. M. Emrich, R. E. Yoast, X. Zhang, A. J. Fike, Y.-H. Wang, K. N. Bricker, A. Tao, P. Xin, V. Walter, M. T. Johnson, T. Pathak, A. C. Straub, S. Feske, Z. Rahman, M. Trebak

This study shows Orai1 and Orai3 are essential for CRAC channel function and metabolic reprogramming in B cells, impacting proliferation, survival, and metabolic processes.

bioRxiv · May 6, 2022Immunology

Curcumin and NCLX Inhibitors Share Anti-Tumoral Mechanisms in Microsatellite-Instability-Driven Colorectal Cancer

M. Gueguinou, S. Ibrahim, J. Bourgeais, A. Robert, T. Pathak, X. Zhang, D. Crottes, J. Dupuy, D. Ternant, V. Monbet, R. Guibon, H. Flores-Romero, A. Lefevre, S. Lerondel, A. Le Pape, , T. Lecomte

This study identifies NCLX as a therapeutic target in MSI-driven CRC, showing that curcumin and NCLX inhibitors induce anti-tumoral effects through mitochondrial calcium overload and apoptosis.

bioRxiv · Jan 18, 2022Cancer Biology

Functional Communication between IP3R and STIM2 at sub-threshold stimuli is a critical checkpoint for initiation of SOCE

M. Ahmad, H. L. Ong, H. Saadi, G.-Y. Son, Z. Shokatian, L. E. Terry, M. Trebak, D. I. Yule, I. Ambudkar

This study identifies IP3R-mediated local [Ca2+]ER decreases as the driver of immobile STIM2 clusters at ER-PM junctions, marking a checkpoint for SOCE initiation under sub-threshold stimuli.

bioRxiv · Sep 24, 2021 · PreprintPhysiology

Peripheral Coupling Sites Formed by STIM1 Govern the Contractility of Vascular Smooth Muscle Cells

V. Krishnan, S. Ali, A. L. Gonzales, P. Thakore, C. S. Griffin, E. Yamasaki, M. G. Alvarado, M. T. Johnson, M. Trebak, S. Earley

This study shows that STIM1 maintains peripheral coupling in vascular smooth muscle cells, essential for contractility, independent of ER Ca2+ store depletion.

bioRxiv · May 25, 2021Physiology

Regulation of Interorganellar Ca2+ Transfer and NFAT Activation by the Mitochondrial Ca2+ Uniporter

R. E. Yoast, S. M. Emrich, X. Zhang, P. Xin, V. Arige, T. Pathak, J. C. Benson, M. T. Johnson, N. Lakomski, N. Hempel, J. M. Han, G. Dupont, D. I. Yule, J. Sneyd, M. Trebak

This study investigates how mitochondrial Ca2+ uniporter (MCU) regulates interorganellar Ca2+ signaling and NFAT activation, showing that MCU-KO increases cytosolic Ca2+ despite reduced CRAC channel activity.

bioRxiv · Apr 7, 2021Cell Biology

Omnitemporal choreographies of IP3R and all five STIM/Orai underlie the complexity of mammalian Ca2+ signaling

S. M. Emrich, R. E. Yoast, P. Xin, V. Arige, L. E. Wagner, N. Hempel, D. L. Gill, J. Sneyd, D. I. Yule, M. Trebak

This paper shows that all five STIM1/2 and Orai1/2/3 isoforms, along with IP3R, work together in a graded manner to ensure precise and diverse Ca2+ signaling in mammals.

bioRxiv · Oct 4, 2020Physiology

The lysosomal TRPML1 channel promotes breast cancer survival by supporting mitochondrial function and cellular metabolism

S. Almasi, B. E. Kennedy, R. E. Yoast, S. M. Emrich, M. Trebak, Y. El Hiani

This study shows TRPML1 promotes TNBC survival by supporting mitochondrial function and metabolism, and its inhibition enhances chemotherapy effectiveness.

bioRxiv · Sep 4, 2020 · PreprintCancer Biology

Colorectal adenocarcinomas downregulate the mitochondrial Na+/Ca2+ exchanger NCLX to drive metastatic spread

T. Pathak, M. Gueguinou, V. Walter, C. Delierneux, M. T. Johnson, X. Zhang, P. Xin, R. E. Yoast, S. M. Emrich, G. S. Yochum, I. Sekler, W. A. Koltun, D. L. Gill, N. Hempel, M. Trebak

This study shows that reduced NCLX expression in colorectal tumors leads to mtCa2+ overload, promoting metastasis and chemoresistance through mtROS/HIF1 signaling.

bioRxiv · May 7, 2020 · PreprintCancer Biology