Author

J. M. Heffernan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Assay:flow cytometry· 3 Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Assay:CITE-seq· 1

Frequent Co-Authors

A.-C. Gingras· 2 shared M. Ostrowski· 2 shared P. Samaan· 2 shared R. Law· 2 shared A. A. Sharma· 1 shared A. Estacio· 1 shared A. Imran· 1 shared A. McGeer· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

A.-C. Gingras

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Author profile →

3 papers

Recent·Most cited

Immunogenicity of COVID-19 vaccines and their effect on the HIV reservoir in older people with HIV

V. A. Matveev, E. Z. Mihelic, E. Benko, P. Budylowski, S. Grocott, T. Lee, C. S. Korosec, K. Colwill, H. Stephenson, R. Law, L. A. Ward, S. Sheikh-Mohamed, G. Mailhot, M. Delgado-Brand, A. Pasculescu, , M. Ostrowski

This study evaluates the immunogenicity of COVID-19 vaccines in older people with HIV and their impact on HIV reservoirs, finding that three doses are needed for optimal neutralizing responses but vaccines may increase HIV reservoirs in those with persistent viremia.

bioRxiv · Jun 14, 2023Immunology

Longitudinal Assessment of SARS-CoV-2 Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multi-Cytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity

J. Lin, R. Law, C. Korosec, C. Zhou, W. H. Koh, M. S. Ghaemi, P. Samaan, H. K. Ooi, F.-Y. Yue, A.-C. Gingras, A. Estacio, M. Buccholz, P. L. Cheatley, K. Pavenski, S. Mubareka, , M. Ostrowski

This study tracks SARS-CoV-2-specific T cell cytokine responses over one year, finding persistent multi-cytokine production with greater immunity linked to disease severity.

bioRxiv · Jan 18, 2022 · PreprintImmunology

Infusion of CCR5 Gene-Edited T Cells Allows Immune Reconstitution, HIV Reservoir Decay, and Long-Term Virological Control

J. Zeidan, A. A. Sharma, G. Lee, A. Raad, R. Fromentin, S. Fourati, K. Ghneim, G. P. Sanchez, C. Benne, G. Canderan, F. A. Procopio, R. Balderas, G. Monette, J. P. Lalezari, J. M. Heffernan, , R.-P. Sekaly

This study shows that infusing CCR5 gene-edited T cells improves immune function, reduces HIV reservoirs, and enables long-term viral control without ART.

bioRxiv · Feb 28, 2021 · PreprintImmunology