Author

A. A. Sharma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:human· 6 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:proteomics· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Assay:flow cytometry· 2

Frequent Co-Authors

R.-P. Sekaly· 3 shared K. Ghneim· 2 shared R. Balderas· 2 shared R. P. Sekaly· 2 shared S. Deeks· 2 shared S. Fourati· 2 shared A. B. Frias· 1 shared A. E. Obuku· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersImmunology

R.-P. Sekaly

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Impaired HIV-specific T-cell responses in HIV and S. mansoni coinfected Ugandans.

A. E. Obuku, A. A. Sharma, A. Rukundo, M. Odong, B. Auma, J. S. Serwanga, R. Nkangi, Z. Nakitto, M. Joloba, G. Pantaleo, P. Kaleebu, R. P. Sekaly

The paper examines how S. mansoni infection impacts HIV-specific T-cell responses in coinfected Ugandan fishermen, finding reduced immune responses after parasite clearance.

bioRxiv · Nov 1, 2022 · PreprintImmunology

HIV-specific CD8 T cells from elite controllers have an epigenetic imprint that preserves effector functions

A. B. Frias, R. L. Rutishauser, A. A. Sharma, T. Mi, C. Zebley, C. M. Constantz, H. A. Abdelsamed, M. Stone, M. P. Busch, S. Deeks, R.-P. Sekaly, B. Youngblood

This study identifies epigenetic and transcriptional features in HIV-specific CD8 T cells from elite controllers that support long-lived effector functions and developmental potential.

bioRxiv · Sep 28, 2021 · PreprintImmunology

Infusion of CCR5 Gene-Edited T Cells Allows Immune Reconstitution, HIV Reservoir Decay, and Long-Term Virological Control

J. Zeidan, A. A. Sharma, G. Lee, A. Raad, R. Fromentin, S. Fourati, K. Ghneim, G. P. Sanchez, C. Benne, G. Canderan, F. A. Procopio, R. Balderas, G. Monette, J. P. Lalezari, J. M. Heffernan, , R.-P. Sekaly

This study shows that infusing CCR5 gene-edited T cells improves immune function, reduces HIV reservoirs, and enables long-term viral control without ART.

bioRxiv · Feb 28, 2021 · PreprintImmunology

Microbiome and Metabolome driven differentiation of TGF-beta producing Tregs leads to Senescence and HIV latency

K. Ghneim, A. A. Sharma, S. P. Ribeiro, S. Fourati, J. Ahlers, D. Kulpa, X. Xu, J. Brehm, A. Talla, S. Arumugam, S. Darko, B. Rodriguez, C. Shive, R. Cristescu, A. Loboda, , R.-P. Sekaly

The paper identifies cellular senescence and TGF-beta pathways in HIV-infected individuals that contribute to HIV latency and poor immune recovery, suggesting potential therapeutic targets.

bioRxiv · Dec 15, 2020 · PreprintImmunology

Looking for pathways related to COVID-19 phenotypes: Confirmation of pathogenic mechanisms by SARS-CoV-2 - Host interactome.

F. Messina, E. Giombini, C. Montaldo, A. A. Sharma, M. Piacentini, A. Zoccoli, R. P. Sekaly, F. Locatelli, A. Zumla, M. Maeurer, M. R. Capobianchi, F. N. Lauria, G. Ippolito

The paper identifies host-virus interactions and specific SARS-CoV-2 proteins involved in severe COVID-19 phenotypes using network analysis.

bioRxiv · Nov 3, 2020Microbiology

Plasmodium oocysts respond with dormancy to crowding and nutritional stress

T. Habtewold, A. A. Sharma, E. K. G. Masters, C. A. S. Wyer, N. Windbichler, G. K. Christophides

The paper shows that Plasmodium oocysts reduce growth under crowding and nutritional stress by entering a dormancy-like state, suggesting the need for improved methods to assess malaria transmission blocking interventions.

bioRxiv · Mar 7, 2020Microbiology