Infusion of CCR5 Gene-Edited T Cells Allows Immune Reconstitution, HIV Reservoir Decay, and Long-Term Virological Control
J. Zeidan, A. A. Sharma, G. Lee, A. Raad, R. Fromentin, S. Fourati, K. Ghneim, G. P. Sanchez, C. Benne, G. Canderan, F. A. Procopio, R. Balderas, G. Monette, J. P. Lalezari, J. M. Heffernan, , R.-P. Sekaly
This study shows that infusing CCR5 gene-edited T cells improves immune function, reduces HIV reservoirs, and enables long-term viral control without ART.
bioRxiv · Feb 28, 2021 · PreprintImmunology