Author

R. Balderas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

R.-P. Sekaly· 3 shared A. A. Sharma· 2 shared K. Ghneim· 2 shared S. Deeks· 2 shared S. Fourati· 2 shared X. Xu· 2 shared A. A. Schonnesen· 1 shared A. Loboda· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersImmunology

R.-P. Sekaly

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Author profile →

4 papers

Recent·Most cited

High-Throughput and High-Dimensional Single Cell Analysis of Antigen-Specific CD8+ T cells

K.-Y. Ma, A. A. Schonnesen, C. He, A. Y. Xia, E. Sun, E. Chen, K. R. Sebastian, R. Balderas, M. Kulkarni-Date, N. Jiang

This study introduces TetTCR-SeqHD, a method to profile antigen-specific CD8+ T cells, revealing unique phenotypes and cross-reactive TCRs in type 1 diabetes.

bioRxiv · Mar 4, 2021Immunology

Infusion of CCR5 Gene-Edited T Cells Allows Immune Reconstitution, HIV Reservoir Decay, and Long-Term Virological Control

J. Zeidan, A. A. Sharma, G. Lee, A. Raad, R. Fromentin, S. Fourati, K. Ghneim, G. P. Sanchez, C. Benne, G. Canderan, F. A. Procopio, R. Balderas, G. Monette, J. P. Lalezari, J. M. Heffernan, , R.-P. Sekaly

This study shows that infusing CCR5 gene-edited T cells improves immune function, reduces HIV reservoirs, and enables long-term viral control without ART.

bioRxiv · Feb 28, 2021 · PreprintImmunology

IL-10 driven memory T cell survival and Tfh differentiation promote HIV persistence

S. Pereira Ribeiro, M. Aid, F. P. Dupuy, C. Ngai Chan, J. Hultquist, C. Deleage, E. Moysi, D. A. Kulpa, L. Li, X. Xu, B. Tamilselvan, J. A. Tomalka, M. Nekorchuk, K. Busman-Sahay, R. Bordi, , R.-P. Sekaly

The paper shows IL-10 promotes HIV persistence by supporting memory T cell survival and Tfh differentiation, and inhibiting IL-10 reduces HIV reservoirs.

bioRxiv · Feb 26, 2021 · PreprintImmunology

Microbiome and Metabolome driven differentiation of TGF-beta producing Tregs leads to Senescence and HIV latency

K. Ghneim, A. A. Sharma, S. P. Ribeiro, S. Fourati, J. Ahlers, D. Kulpa, X. Xu, J. Brehm, A. Talla, S. Arumugam, S. Darko, B. Rodriguez, C. Shive, R. Cristescu, A. Loboda, , R.-P. Sekaly

The paper identifies cellular senescence and TGF-beta pathways in HIV-infected individuals that contribute to HIV latency and poor immune recovery, suggesting potential therapeutic targets.

bioRxiv · Dec 15, 2020 · PreprintImmunology