Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis
J. M. Hendricks, C. Doubravsky, E. Wehri, Z. Li, M. A. Roberts, K. Deol, M. Lange, I. Lasheras-Otero, S. J. Dixon, K. Bersuker, J. Schaletzky, J. A. Olzmann
This study identifies structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis, with FSEN1 showing potent on-target inhibition and synergy with ferroptosis inducers.
Cell Chemical Biology · Sep 1, 2023Peer-reviewedCancer Biology