Author

M. A. Roberts

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1

Frequent Co-Authors

J. A. Olzmann· 3 shared K. K. Deol· 2 shared M. C. Bassik· 2 shared M. Lange· 2 shared S. J. Dixon· 2 shared Z. Li· 2 shared A. J. Mathiowetz· 1 shared C. Doubravsky· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCell Biology

J. A. Olzmann

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis

J. M. Hendricks, C. Doubravsky, E. Wehri, Z. Li, M. A. Roberts, K. Deol, M. Lange, I. Lasheras-Otero, S. J. Dixon, K. Bersuker, J. Schaletzky, J. A. Olzmann

This study identifies structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis, with FSEN1 showing potent on-target inhibition and synergy with ferroptosis inducers.

Cell Chemical Biology · Sep 1, 2023Peer-reviewedCancer Biology

Parallel CRISPR-Cas9 screens reveal mechanisms of PLIN2 and lipid droplet regulation

M. A. Roberts, K. K. Deol, M. Lange, D. E. Leto, A. J. Mathiowetz, J. Stevenson, S. H. Hashemi, D. W. Morgens, E. Easter, K. Heydari, M. A. Nalls, M. C. Bassik, M. Kampmann, R. R. Kopito, F. Faghri, J. A. Olzmann

The paper uses CRISPR-Cas9 screens to identify genes regulating PLIN2 and lipid droplet abundance, revealing new mechanisms and creating a resource for lipid metabolism research.

bioRxiv · Aug 27, 2022 · PreprintCell Biology

VPS13A and VPS13C influence lipid droplet abundance

S. Chen, M. A. Roberts, C.-Y. Chen, S. Markmiller, H.-G. Wei, G. W. Yeo, J. G. Granneman, J. A. Olzmann, S. Ferro-Novick

This study shows that loss of VPS13A or VPS13C reduces lipid droplet abundance in cells under oleate-stimulated conditions.

bioRxiv · Jun 21, 2022Cell Biology

Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability in cancer

Z. Li, L. Ferguson, K. K. Deol, M. A. Roberts, L. Magtanong, M. C. Bassik, S. J. Dixon, N. Ingolia, J. Olzmann

The paper identifies LRP8 as a ferroptosis resistance factor in cancer, showing that its loss causes ribosome stalling during GPX4 translation, exposing a vulnerability in cancer cells.

bioRxiv · Apr 11, 2022Cancer Biology