S. J. Dixon

Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis

This study identifies structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis, with FSEN1 showing potent on-target inhibition and synergy with ferroptosis inducers.

A Cell Cycle-Dependent Ferroptosis Sensitivity Switch Governed by EMP2

The paper shows cell cycle arrest increases sensitivity to GPX4 inhibitor-induced ferroptosis via elevated oxidizable phospholipids and reduced EMP2 expression.

Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability in cancer

The paper identifies LRP8 as a ferroptosis resistance factor in cancer, showing that its loss causes ribosome stalling during GPX4 translation, exposing a vulnerability in cancer cells.

Nucleotide Biosynthesis Links Glutathione Metabolism to Ferroptosis Sensitivity

The paper shows that p53 inhibition of nucleotide metabolism reduces ferroptosis by preserving glutathione levels through RNR suppression.

Ferroptosis Regulation by the NGLY1/NFE2L1 Pathway

This study identifies the NGLY1/NFE2L1 pathway as a regulator of ferroptosis, showing that NGLY1-mediated deglycosylation of NFE2L1 is necessary for its anti-ferroptotic function through GPX4 expression.

A novel small molecule that induces cytotoxicity in lung cancer cells inhibits disulfide reductases GSR and TXNRD1

The paper identifies LCS3, a compound that induces oxidative stress in lung cancer cells by inhibiting disulfide reductases GSR and TXNRD1, and shows its synergistic effect with glutathione and thioredoxin pathway inhibition.

Oxaliplatin kills cells via liquid-liquid demixing of nucleoli

This study shows oxaliplatin causes nucleolar liquid-liquid demixing, leading to cell death by disrupting nucleolar organization and transcription.

Large-Scale Analysis of Cell Death Phenotypic Heterogeneity

This study quantifies and compares fractional killing of cancer cells across multiple lethal agents and cell lines using high-throughput time-lapse imaging, revealing MCL1's role in MAPK inhibitor-induced cell death.

Dietary Induction and Modulation of Ferroptosis in Caenorhabditis elegans

This study shows that dietary DGLA induces ferroptosis-like germ cell death in C. elegans, modulated by antioxidants, iron chelators, and oleic acid, and also triggers ferroptosis in human cells.