J. M. Hernandez-Rivas

This paper applies Hierarchical Dirichlet Mixture Models to binary genomic data in AML to improve patient stratification and clustering through statistical refinements.

This study uses CRISPR/Cas9 to target and disrupt the BCR/ABL1 oncogene in CML cells, restoring normal hematopoiesis in mouse models and patient-derived xenografts.

This study abrogates the ETV6/RUNX1 fusion gene in a preclinical model of acute lymphoblastic leukemia, showing reduced oncogenic potential through increased apoptosis and decreased proliferation.