CRISPR/Cas9 technology abolishes the BCR/ABL1 oncogene effect in chronic myeloid leukemia and restores normal hematopoiesis
E. Vuelta, J. L. Ordonez, V. Alonso-Perez, L. Mendez, P. Hernandez-Carabias, R. Saldana, J. Sevilla, E. Sebastian, S. Muntion, F. Sanchez-Guijo, J. M. Hernandez-Rivas, I. Garcia-Tunon, M. A. Sanchez-Martin
This study uses CRISPR/Cas9 to target and disrupt the BCR/ABL1 oncogene in CML cells, restoring normal hematopoiesis in mouse models and patient-derived xenografts.
bioRxiv · Aug 5, 2020 · PreprintCancer Biology